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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

The Medicinal Potential of Influenza Virus Surface Proteins: Hemagglutinin and Neuraminidase

Author(s): Y. Xie, J. Gong, M. Li, H. Fang and W. Xu

Volume 18 , Issue 7 , 2011

Page: [1050 - 1066] Pages: 17

DOI: 10.2174/092986711794940815

Price: $65

Abstract

Nowadays, influenza virus is still a big threat to human. Hemagglutinin (HA) and neuraminidase (NA) are the two viral surface proteins, which play important roles in the life cycle of influenza virus. Current influenza vaccines and anti-influenza drugs work mainly by interfering with the functions of the two proteins. In this review, we will display some recent studies about the two proteins. As to HA, this review covers a lot including its fusion function, receptor specificity, antigenic shift hypothesis, novel antibodies and various inhibitors in order to deeply discuss this protein. As to NA, this review mainly focuses on studies about the newly identified 150-cavity of group-1 NAs and shows some untypical NA inhibitors aiming to provide a broader range of lead compounds for anti-influenza drug design.

Keywords: Antibody, antigenic shift, hemagglutinin, influenza, inhibitor, membrane fusion, neuraminidase, receptor specificity, anti-influenza drugs, group-1 NAs


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