Abstract
Metabolic profiling employs a combination of sophisticated analytical tools to obtain global “untargeted” metabolic profiles from tissues, cells or biofluids. The resulting complex multivariate data are then modeled statistically to reveal differences between classes (e.g. dosed vs. control) and identify discriminatory metabolites. Metabolic profiling has a wide range of applications, encompassing nutrition, disease diagnosis, epidemiology and toxicology, providing insights into altered biological pathways and offering fresh mechanistic perspectives. Further, the untargeted nature of metabolic profiling can allow for new biomarkers of disease or toxic effect to be uncovered. In this review, key metabolic profiling technologies will be introduced and data analysis approaches described briefly. The role of metabolic profiling in disease diagnosis, toxicology and personalized healthcare will be discussed.
Keywords: Metabolic profiling, NMR spectroscopy, mass spectrometry, toxicology, metabonomics, multivariate, statistics, biomarker, diagnostic, epidemiology and toxicology, data analysis approaches, gas chromatography, capillary electrophoresis
Current Pharmaceutical Biotechnology
Title: Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare
Volume: 12 Issue: 7
Author(s): M. Anas Kamleh, Konstantina Spagou and Elizabeth J. Want
Affiliation:
Keywords: Metabolic profiling, NMR spectroscopy, mass spectrometry, toxicology, metabonomics, multivariate, statistics, biomarker, diagnostic, epidemiology and toxicology, data analysis approaches, gas chromatography, capillary electrophoresis
Abstract: Metabolic profiling employs a combination of sophisticated analytical tools to obtain global “untargeted” metabolic profiles from tissues, cells or biofluids. The resulting complex multivariate data are then modeled statistically to reveal differences between classes (e.g. dosed vs. control) and identify discriminatory metabolites. Metabolic profiling has a wide range of applications, encompassing nutrition, disease diagnosis, epidemiology and toxicology, providing insights into altered biological pathways and offering fresh mechanistic perspectives. Further, the untargeted nature of metabolic profiling can allow for new biomarkers of disease or toxic effect to be uncovered. In this review, key metabolic profiling technologies will be introduced and data analysis approaches described briefly. The role of metabolic profiling in disease diagnosis, toxicology and personalized healthcare will be discussed.
Export Options
About this article
Cite this article as:
Anas Kamleh M., Spagou Konstantina and J. Want Elizabeth, Metabolic Profiling in Disease Diagnosis, Toxicology and Personalized Healthcare, Current Pharmaceutical Biotechnology 2011; 12 (7) . https://dx.doi.org/10.2174/138920111795909069
DOI https://dx.doi.org/10.2174/138920111795909069 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
Call for Papers in Thematic Issues
Artificial Intelligence in Bioinformatics
Bioinformatics is an interdisciplinary field that analyzes and explores biological data. This field combines biology and information system. Artificial Intelligence (AI) has attracted great attention as it tries to replicate human intelligence. It has become common technology for analyzing and solving complex data and problems and encompasses sub-fields of machine ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Pleiotropic Effects of ARB in Vascular Metabolism - Focusing on Atherosclerosis-Based Cardiovascular Disease
Current Vascular Pharmacology Structure-Activity Relationships of Flavonoids
Current Organic Chemistry Stacking Regression Algorithms to Predict PM<sub>2.5</sub> in the Smart City Using Internet of Things
Recent Advances in Computer Science and Communications Impact of Hyperhomocyst(e)inemia on Endothelial Function
Vascular Disease Prevention (Discontinued) Editorial: [Statins and Cardiovascular Events in Patients with End-Stage Renal Disease on Hemodialysis. The AURORA Results Suggest the Need for Earlier Intervention]
Current Vascular Pharmacology Conjugation of Resveratrol with RGD and KGD Derivatives
Protein & Peptide Letters Cardiovascular Effects of Methotrexate in Rheumatoid Arthritis Revisited
Current Medicinal Chemistry Bidirectional Nature of Cardiovascular and Kidney Disease
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Systematic Review of the Role of Microparticles in Systemic Sclerosis
Current Rheumatology Reviews Perioperative Safety of Warfarin Therapy and Reversal
Current Drug Safety Rationalizing the Study of Plants for the Treatment of Oral Pain
Current Chemical Biology The role of interleukin 35 in atherosclerosis
Current Pharmaceutical Design Polypharmacology in a Single Drug: Multitarget Drugs
Current Medicinal Chemistry Cardiac Stem Cell Characteristics in Physiological and Pathological Conditions
Current Pharmaceutical Design The Relationship Between Hypertensive Retinopathy and Angiotensin Converting Enzyme Gene Polymorphism
Cardiovascular & Hematological Disorders-Drug Targets The Short and Long-Term Efficacy of Pulmonary Vein Isolation as a Sole Treatment Strategy for Paroxysmal Atrial Fibrillation: A Systematic Review and Meta-Analysis
Current Cardiology Reviews Long-Term Bronchodilator Inhaled Therapy in COPD: The Role of Tiotropium Bromidum
Reviews on Recent Clinical Trials Statins And Stroke
Current Medicinal Chemistry Matrix Gelatinases in Atherosclerosis and Diabetic Nephropathy: Progress and Challenges
Current Vascular Pharmacology Human Sirtuins: An Overview of an Emerging Drug Target in Age-Related Diseases and Cancer
Current Drug Targets