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Protein & Peptide Letters


ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Amyloid Under the Atomic Force Microscope

Author(s): Walraj S. Gosal, Sarah L. Myers, Sheena E. Radford and Neil H. Thomson

Volume 13 , Issue 3 , 2006

Page: [261 - 270] Pages: 10

DOI: 10.2174/092986606775338498

Price: $65


The atomic force microscope (AFM) is a versatile instrument that can be used to image biological samples at nanometre resolution as well as to measure inter and intra-molecular forces in air and liquid environments. This review summarises the use of AFM applied to protein and peptide self-assembly systems involved in amyloid formation. The technical principles of the AFM are outlined and its advantages and disadvantages are highlighted and discussed in the context of the rapidly developing field of amyloid research.

Keywords: Tapping mode, contact mode, functional surfaces, time-lapse microscopy, 3D topography, self-assembly, amyloid fibrils, biomimetic environments

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