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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Selection of An Unnatural Peptide Library For dsDNA Binding

Author(s): Zhenyu Zhang and Piet Herdewijn

Volume 8 , Issue 5 , 2001

Page: [517 - 531] Pages: 15

DOI: 10.2174/0929867003373355

Price: $65

Abstract

More and more, nucleic acids have become prime targets in the development of new compounds, able to control gene expression. For the development of new sequence selective dsDNA binding ligands, one can learn a lot from existing models such as, lexitropsins, combilexins and actinomycin D. This analysis, together with the knowledge of the details on protein-DNA interactions, has inspired the assembly of unnatural amino acids in a combinatorial way to generate a dsDNA recognition library. The first selection round has led to the selection of new DNA binding molecules, which may lead on the long run to the discovery of new DNA binding motifs.


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