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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Sequence Recognition of DNA by Lexitropsins

Author(s): David S. Goodsell

Volume 8 , Issue 5 , 2001

Page: [509 - 516] Pages: 8

DOI: 10.2174/0929867003373319

Price: $65

Abstract

Lexitropsins are modular polyamide molecules that are designed to “read” the base sequence of DNA. Lexitropsins constructed of three types of subunits-- pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.


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