Abstract
In vivo magnetic resonance spectroscopy is a powerful tool which can be applied non-invasively to monitor disease progression at a molecular level in the brain of human patients with Alzheimers disease (AD) and transgenic mouse models of AD. Application of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in transgenic mouse models of AD makes it possible to follow metabolic changes and structural changes at the same time longitudinally. This review focuses on in vivo MRS studies in transgenic mouse models of AD and highlights the future impact of MRS techniques in finding crucial biomarkers of AD.
Keywords: Alzheimer's Disease, magnetic resonance spectroscopy, transgenic mouse models, N-acetylaspartate NAA, APP, APP/PS1
Current Medical Imaging
Title: Prospects of Magnetic Resonance Spectroscopy in Mouse Models of Alzheimers Disease
Volume: 7
Author(s): Firat Kara, Niels Braakman, Mark A. van Buchem, Huub J. M. de Groot and A. Alia
Affiliation:
Keywords: Alzheimer's Disease, magnetic resonance spectroscopy, transgenic mouse models, N-acetylaspartate NAA, APP, APP/PS1
Abstract: In vivo magnetic resonance spectroscopy is a powerful tool which can be applied non-invasively to monitor disease progression at a molecular level in the brain of human patients with Alzheimers disease (AD) and transgenic mouse models of AD. Application of magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS) in transgenic mouse models of AD makes it possible to follow metabolic changes and structural changes at the same time longitudinally. This review focuses on in vivo MRS studies in transgenic mouse models of AD and highlights the future impact of MRS techniques in finding crucial biomarkers of AD.
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Cite this article as:
Kara Firat, Braakman Niels, A. van Buchem Mark, J. M. de Groot Huub and Alia A., Prospects of Magnetic Resonance Spectroscopy in Mouse Models of Alzheimers Disease, Current Medical Imaging 2011; 7 (1) . https://dx.doi.org/10.2174/157340511794653469
DOI https://dx.doi.org/10.2174/157340511794653469 |
Print ISSN 1573-4056 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6603 |
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