Generic placeholder image

Current Organic Chemistry


ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Recent Advances in the Regioselective Synthesis of Pyrazoles

Author(s): Joo-Yong Yoon, Sang-gi Lee and Hyunik Shin

Volume 15, Issue 5, 2011

Page: [657 - 674] Pages: 18

DOI: 10.2174/138527211794519005

Price: $65


Pyrazole is the ubiquitous sub-structure of many natural products and biologically active compounds. In this respect, its regioselective synthesis drew a lot of attention from synthetic organic chemists, leading to the development of various regioselective modifications of the classical Knorr cyclocondensation reaction and alternative methods. This review covers the period of 2003 to the middle of 2009 on the regioselective synthesis of pyrazoles, which are categorized into four reaction types: (i) modified Knorr condensation reaction using 1,3-dicarbonyl surrogates; (ii) 1,3-dipolar cycloadditions approach; (iii) regioselective direct substitution reaction of the pyrazole ring system; and (iv) other methods.

Keywords: Pyrazole, regioselective dipolar cycloaddition, regioselective condensation, regioselective cross-coupling

Rights & Permissions Print Export Cite as
© 2023 Bentham Science Publishers | Privacy Policy