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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Fries-type Reactions for the C-Glycosylation of Phenols

Author(s): Rui G. dos Santos, Ana R. Jesus, Joao M. Caio and Amelia P. Rauter

Volume 15, Issue 1, 2011

Page: [128 - 148] Pages: 21

DOI: 10.2174/138527211793797855

Price: $65

Abstract

C-Glycosylphenols and -polyphenols occur widely in nature and present a variety of biological properties, namely antitumor, antibacterial and antidiabetic activities. Synthetic access to such structures relies mainly on efficient methodologies for phenols C-glycosylation. In the past few years major advances have been described addressing the use of Fries rearrangement to obtain a diversity of C-glycosyl compounds. Herein we survey the glycosyl donors and the activators used for this reaction, covering both early work and recent developments in the area. Reaction mechanism and reaction outcome control, aiming at regio- and stereoselectivity are also discussed.

Keywords: Phenols C-glycosylation, Fries-type rearrangement, activator, C-Glycosylphenols, Cglycosylation, stereoselectivity, antibiotics pluramycins, samarium iodide, boron trifluoride, oxonium ion, sugar trichloroacetimidates, Tin Chloride, ribofuranosyl fluoride, vineomycin B2, naphthols, Glycosyl acetates, rhamnosyl acetate, dichloromethane, pluramycins, resorcinol, mannosyl fluoride, Montmorillonite K-10


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