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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles

Author(s): A. S. Carvalho, D. Gibaldi, A. C. Pinto, M. Bozza and N. Boechat

Volume 3 , Issue 2 , 2006

Page: [98 - 101] Pages: 4

DOI: 10.2174/157018006775789667

Price: $65

Abstract

A new series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles (6ah) has been designed, synthesized and examined for their ability against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution. Several bases were investigated as proton scavengers, and lithium diisopropylamide (LDA) was found to be the best base giving products in good yields.

Keywords: 1,3,4-thiadiazole derivative, nucleophilic aromatic substitution, megazol, trypanocidal activity


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