Abstract
A new series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles (6ah) has been designed, synthesized and examined for their ability against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution. Several bases were investigated as proton scavengers, and lithium diisopropylamide (LDA) was found to be the best base giving products in good yields.
Keywords: 1,3,4-thiadiazole derivative, nucleophilic aromatic substitution, megazol, trypanocidal activity
Letters in Drug Design & Discovery
Title: Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles
Volume: 3 Issue: 2
Author(s): A. S. Carvalho, D. Gibaldi, A. C. Pinto, M. Bozza and N. Boechat
Affiliation:
Keywords: 1,3,4-thiadiazole derivative, nucleophilic aromatic substitution, megazol, trypanocidal activity
Abstract: A new series of 5-[N-(3-(5-substituted)-1,3,4-thiadiazolyl)]amino-1-methyl-4-nitroimidazoles (6ah) has been designed, synthesized and examined for their ability against Trypanosoma cruzi. The compounds were prepared by nucleophilic aromatic substitution. Several bases were investigated as proton scavengers, and lithium diisopropylamide (LDA) was found to be the best base giving products in good yields.
Export Options
About this article
Cite this article as:
Carvalho S. A., Gibaldi D., Pinto C. A., Bozza M. and Boechat N., Synthesis and Trypanocidal Evaluation of News 5-[N-(3-(5-Substituted)- 1,3,4-Thiadiazolyl)]Amino-1-Methyl-4-Nitroimidazoles, Letters in Drug Design & Discovery 2006; 3 (2) . https://dx.doi.org/10.2174/157018006775789667
DOI https://dx.doi.org/10.2174/157018006775789667 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers