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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Improved Sensory Blockade by Clonidine Added to Axillary Block Solution. Resulting Plasma Clonidine Concentration

Author(s): Jean-Marc Bernard

Volume 3 , Issue 2 , 2006

Page: [87 - 90] Pages: 4

DOI: 10.2174/157018006775789739

Price: $65


In this prospective, randomized, double-blinded study, clonidine was found an efficient adjunct to local anesthetics for increasing the intensity of axillary brachial plexus block. Similar clonidine dose had no such effect when administered intramuscularly, suggesting a local, neural effect. Blood absorption was similar in both cases, leading to central action as sedation.

Keywords: Adrenergic agonists, adrenergic a-agonists, anesthesia, conduction, nerve block, pharmacology, plasma clonidine concentration

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