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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Antitumor Activity of 20-O-Linked Succinate-Based Camptothecin Ester Derivatives

Author(s): Hua Lu, Haixia Lin, Yi Jiang, Xinguang Zhou, Beili Wu and Jianmin Chen

Volume 3 , Issue 2 , 2006

Page: [83 - 86] Pages: 4

DOI: 10.2174/157018006775789757

Price: $65


A series of new 20-O-linked succinate-based camptothecin ester derivatives were synthesized and their cytotoxicities were tested on five human cancer cell lines by MTT assay. All the derivatives showed moderate antitumor activity in vitro, and they were 20-to-several thousand-fold less toxic than their parent drug.

Keywords: Camptothecin, ester, succinate, prodrug, antitumor

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