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Letters in Drug Design & Discovery


ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Synthesis and Evaluation of Aminoglycosides as Inhibitors for Rev binding to Rev Responsive Element

Author(s): Hayamitsu Adachi, Yoshinori Takahashi, Motoki Kyo, Tsuyoshi Sato and Yoshio Nishimura

Volume 3 , Issue 2 , 2006

Page: [71 - 75] Pages: 5

DOI: 10.2174/157018006775789694

Price: $65


Interactions of α-amino or guanidino-α-hydroxybutyryl-aminoglycosides with an essential sequence of Rev responsive element (RRE) in HIV-1 mRNA were evaluated using surface plasmon resonance imaging. Aminoglycosides were proved to bind nonspecifically to RRE.

Keywords: Aminoglycoside, surface plasmon resonance imaging, RNA recognition

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