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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

Synthesis of Functionalized Chromenes from Meldrum’s Acid, 4- Hydroxycoumarin, and Ketones or Aldehydes

Author(s): Maryam Sabbaghan, Issa Yavari and Zinatossadat Hossaini

Volume 13, Issue 9, 2010

Page: [813 - 817] Pages: 5

DOI: 10.2174/138620710792927358

Price: $65

Abstract

An efficient synthesis of 4-alkyl-4-methyl-3,4-dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-dione or 4-aryl-3,4- dihydro-2H,5H-pyrano[3,2-c]chromene-2,5-diones via reaction 4-hydroxycoumarin with Meldrum’s acid and ketones or aldehydes is described.

Keywords: Chromene, proline, aqueous media, meldrum’s acid, 4-hydroxycoumarin


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