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Current Neuropharmacology

Rome
(Italy)

">Editor-in-Chief

ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Anti-Amyloidogenic and Anti-Apoptotic Role of Melatonin in Alzheimer Disease

Author(s): Hongwen He, Weiguo Dong and Fang Huang

Volume 8 , Issue 3 , 2010

Page: [211 - 217] Pages: 7

DOI: 10.2174/157015910792246137

Price: $65

Abstract

Alzheimer disease (AD) is an age-related neurodegenerative disorder characterized by the presence of senile plaques, neurofibrillary tangles and neuronal loss. Amyloid-β protein (Aβ) deposition plays a critical role in the development of AD. It is now generally accepted that massive neuronal death due to apoptosis is a common characteristic in the brains of patients suffering from neurodegenerative diseases, and apoptotic cell death has been found in neurons and glial cells in AD. Melatonin is a secretory product of the pineal gland; melatonin is a potent antioxidant and free radical scavenger and may play an important role in aging and AD. Melatonin decreases during aging and patients with AD have a more profound reduction of this indoleamine. Additionally, the antioxidant properties, the anti-amyloidogenic properties and anti-apoptotic properties of melatonin in AD models have been studied. In this article, we review the antiamyloidogenic and anti-apoptotic role of melatonin in AD.

Keywords: Alzheimer disease, neurodegeneration, neuroprotection, melatonin, amyloid beta-protein, amyloid precursor protein, apoptosis, mitochondria


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