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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Novel Natural and Synthetic Ligands of the Endocannabinoid System

Author(s): Lumir O. Hanus and Raphael Mechoulam

Volume 17 , Issue 14 , 2010

Page: [1341 - 1359] Pages: 19

DOI: 10.2174/092986710790980096

Price: $65

Abstract

In this review we describe recent advances in the chemistry of novel CB1/CB2 agonists, CB1 antagonists, selective CB2 agonists, fatty acid amide hydrolase inibitors, monoglyceride (MGL) and diglyceride (DAGL) inhibitors and cannabinoid-type agonists and antagonists of non CB1/CB2 receptors. In view of recent interest in the activities of fatty acid amides of amino acids (N-acyl amino acids) a list of this type of compounds was compiled and is presented as a Table. We conclude that further synthetic work based on both the plant cannabinoids and on the endocannabinoids may lead to novel therapeutics and that the identification and the elucidation of the biological profile of the myriad of endogenous N-acyl amino acids and related compounds may enhance the already wide spectrum of lipidomics.

Keywords: CB agonists, Endocannabinoids, CB antagonists, FAAH, MGL, DAGL


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