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Current Diabetes Reviews


ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Ambulatory Blood Pressure and Diabetes: Targeting Nondipping

Author(s): Cesare Cuspidi, Alvaro Vaccarella, Gastone Leonetti and Carla Sala

Volume 6 , Issue 2 , 2010

Page: [111 - 115] Pages: 5

DOI: 10.2174/157339910790909378

Price: $65


A reduced fall in nocturnal blood pressure (BP) (i.e. non-dipping) has been related to an increase in target organ damage and cardiovascular (CV) events. Numerous studies have shown that non-dipping is highly prevalent in patients with type 1 and 2 diabetes mellitus. In this paper we reviewed recent literature and our personal data on the prevalence and clinical correlates of abnormal diurnal BP rhythm in diabetic patients; in particular we examined the association of this condition with renal, cardiac, and vascular pre-clinical organ damage as well as CV prognosis. A consistent body of evidence based on cross-sectional and longitudinal studies indicates that the lack of the physiologic nocturnal fall in BP may be considered a true clinical trait, a reliable marker of preclinical CV and renal disease and an independent predictor of future CV events. Thus, in the diabetic setting ambulatory BP monitoring (ABPM) should be regarded as a pivotal tool for improving CV risk stratification and therapeutic interventions.

Keywords: Non-dipping, Diabetes mellitus type 1 and 2, Hypertension, Organ damage, Cardiovascular prognosis

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