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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Mechanisms Involved in the Genesis of Diabetic Nephropathy

Author(s): Ana M. Blazquez-Medela, Jose M. Lopez-Novoa and Carlos Martinez-Salgado

Volume 6 , Issue 2 , 2010

Page: [68 - 87] Pages: 20

DOI: 10.2174/157339910790909422

Price: $65

Abstract

In recent years, the number of people suffering from diabetes has increased notably. This increase has led to an augmentation in secondary diseases; amongst them, diabetic nephropathy (DN) is one of the most relevant pathologies. DN provokes a decrease in glomerular filtration rate, which ends up in chronic renal failure. In the developed countries, DN is the first cause of chronic renal failure needing replacement therapy. Thus, this disease is responsible for a remarkable part of the public health costs in the Western countries. All of these facts have encouraged many scientists to perform their research on mechanism causing DN, improving our knowledge of its pathogenesis. In this review we summarize the most relevant facts on the physiopathology of DN.

Keywords: Diabetes, Nephropathy, Gestational diabetes


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