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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Mucosal Healing and anti TNFs in IBD

Author(s): Gert van Assche, Severine Vermeire and Paul Rutgeerts

Volume 11, Issue 2, 2010

Page: [227 - 233] Pages: 7

DOI: 10.2174/138945010790309902

Price: $65

Abstract

Mucosal healing has been incorporated in the assessment of treatment efficacy in ulcerative colitis, but in Crohns disease this concept has only emerged after biological therapies have been evaluated in clinical trials. Systemic steroids dont induce mucosal healing in Crohns disease, but purine analoges and anti TNF agents have a potential to heal mucosal ulcerations. Evidence for mucosal healing has now been provided for the anti TNF agents infliximab, adalimumab and certolizumab. For infliximab mucosal healing is associated with a reduction in hospitalizations and surgeries. On the contrary, the benefit of treating patients with IBD more intensively until they achieve mucosal healing has not been proven. In clinical practice assessing mucosal healing should be considered in patients with persistent symptoms despite adequate therapy and when treatment discontinuation is being considered.

Keywords: Mucosal healing, endoscopy, medical therapy, IBD, Crohn's disease, ulcerative colitis


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