Abstract
The heart and vascular system represent major targets of the thyroid hormone action, and marked changes occur in cardiac electro-mechanical function of patients with hyper-hypothyroidism. Thyroid hormones exert their effects through both genomic (nuclear) and nongenomic (extranuclear) mechanisms. Understanding the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system is the basis to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm abnormalities secondary to thyroid dysfunction. Not only overt, but also subclinical thyroid diseases have been associated with systolic and diastolic cardiac abnormalities, and with alterations of well known cardiovascular risk factors. Moreover, the early diagnosis and treatment of thyroid diseases restore to normal most of the cardiovascular changes. Nowadays, it is becoming increasingly evident that, like a vicious circle, acute and chronic cardiovascular diseases may influence thyroid hormone metabolism, which, in turn, can contribute to cardiovascular impairment progression.
Keywords: Thyroid hormones, cardiovascular disease, thyroid dysfunction
Current Drug Therapy
Title: Thyroid Hormones and Cardiovascular System: From Bench to Bedside
Volume: 5 Issue: 1
Author(s): Pasquale Di Conza, Flora Affuso and Serafino Fazio
Affiliation:
Keywords: Thyroid hormones, cardiovascular disease, thyroid dysfunction
Abstract: The heart and vascular system represent major targets of the thyroid hormone action, and marked changes occur in cardiac electro-mechanical function of patients with hyper-hypothyroidism. Thyroid hormones exert their effects through both genomic (nuclear) and nongenomic (extranuclear) mechanisms. Understanding the cellular mechanisms of thyroid hormone action on the heart and cardiovascular system is the basis to explain the changes in cardiac output, cardiac contractility, blood pressure, vascular resistance, and rhythm abnormalities secondary to thyroid dysfunction. Not only overt, but also subclinical thyroid diseases have been associated with systolic and diastolic cardiac abnormalities, and with alterations of well known cardiovascular risk factors. Moreover, the early diagnosis and treatment of thyroid diseases restore to normal most of the cardiovascular changes. Nowadays, it is becoming increasingly evident that, like a vicious circle, acute and chronic cardiovascular diseases may influence thyroid hormone metabolism, which, in turn, can contribute to cardiovascular impairment progression.
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Cite this article as:
Conza Di Pasquale, Affuso Flora and Fazio Serafino, Thyroid Hormones and Cardiovascular System: From Bench to Bedside, Current Drug Therapy 2010; 5 (1) . https://dx.doi.org/10.2174/1574885511005010036
DOI https://dx.doi.org/10.2174/1574885511005010036 |
Print ISSN 1574-8855 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3903 |
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