Abstract
A smooth and rapid one step synthesis of novel pyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidines 4a,b and 7, pyrido[2,3:3,4]pyrazolo[5,1-c]triazines10-12a,b, pyrido[3“,2“:4,5]thieno[3,2:4,5]pyrimido/triazino[1,6-a]benzimidazoles 15-20 in synthetically useful yields utilizing, 3-amino-4-phenyl-5-(saccharin-2-yl)-1H-pyrazolo[3,4-b]pyridine (3) were described. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Preliminary biological studies of some synthesized compounds showed promising antimicrobial activities.
Current Organic Chemistry
Title: A Synthetic Approach and Antimicrobial Evaluation of Annulated Pyrimidine and Triazine Derivatives
Volume: 13 Issue: 17
Author(s): A. A. Aly
Affiliation:
Abstract: A smooth and rapid one step synthesis of novel pyrido[2,3:3,4]pyrazolo[1,5-a]pyrimidines 4a,b and 7, pyrido[2,3:3,4]pyrazolo[5,1-c]triazines10-12a,b, pyrido[3“,2“:4,5]thieno[3,2:4,5]pyrimido/triazino[1,6-a]benzimidazoles 15-20 in synthetically useful yields utilizing, 3-amino-4-phenyl-5-(saccharin-2-yl)-1H-pyrazolo[3,4-b]pyridine (3) were described. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Preliminary biological studies of some synthesized compounds showed promising antimicrobial activities.
Export Options
About this article
Cite this article as:
Aly A. A., A Synthetic Approach and Antimicrobial Evaluation of Annulated Pyrimidine and Triazine Derivatives, Current Organic Chemistry 2009; 13 (17) . https://dx.doi.org/10.2174/138527209789578090
DOI https://dx.doi.org/10.2174/138527209789578090 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Prevention and Management of Ovarian Hyperstimulation Syndrome
Current Women`s Health Reviews The Radioprotective Potentials of Silymarin/Silibinin Against Radiotherapy- Induced Toxicities: A Systematic Review of Clinical and Experimental Studies
Current Medicinal Chemistry Recent Patents on the Development of c-Met Kinase Inhibitors
Recent Patents on Anti-Cancer Drug Discovery Alterations in Clinical Characteristics of Blood Donors Post COVID-19 Recovery
Current Pharmaceutical Design Pharmacological Inhibition of MMP3 as a Potential Therapeutic Option for COVID-19 Associated Acute Respiratory Distress Syndrome
Infectious Disorders - Drug Targets Designing Novel Therapies Against Sarcomas in the Era of Personalized Medicine and Economic Crisis
Current Pharmaceutical Design GAMESS As a Free Quantum-Mechanical Platform for Drug Research
Current Topics in Medicinal Chemistry Melatonin and Its Therapeutic Potential in Neuroprotection
Central Nervous System Agents in Medicinal Chemistry Hepatocyte Growth Factor (HGF), an Endogenous Pulmotrophic Regulator, for the Rescue of Acute and Chronic Lung Diseases
Current Signal Transduction Therapy Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo
CNS & Neurological Disorders - Drug Targets The mRNA Technology in Cancer Immunotherapy
Current Nanomaterials Reducing the Risk of Major Elective Non-cardiac Surgery: Is there a Role for Levosimendan in the Preoperative Optimization of Cardiac Function?
Current Drug Targets The Appearance of Middle Meningeal Artery Fistulae After Willis Covered Stent for Traumatic Carotid-cavernous Fistulae: Two Case Reports
Current Medical Imaging Peptides for Tumour Therapy and Diagnosis: Current Status and Future Directions
Current Medicinal Chemistry COVID-19 and Diabetes Mellitus: Potential Metabolic Associations
Current Topics in Medicinal Chemistry The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication
Current Pharmaceutical Design 4-Aminoquinoline Based Molecular Hybrids as Antimalarials: An Overview
Current Topics in Medicinal Chemistry A Multi-Scale Parameterization Approach of Peptides for Quantitative Sequence-Activity Models
Protein & Peptide Letters <i>In Silico</i> Design and Synthesis of Targeted Curcumin Derivatives as Xanthine Oxidase Inhibitors
Current Drug Targets The Structure-AChE Inhibitory Activity Relationships Study in a Series of Pyridazine Analogues
Medicinal Chemistry