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Combinatorial Chemistry & High Throughput Screening

Editor-in-Chief

ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

“Seeing is Believing”: Perspectives of Applying Imaging Technology in Discovery Toxicology

Author(s): Jinghai James Xu, Margaret Condon Dunn and Arthur Russell Smith

Volume 12 , Issue 9 , 2009

Page: [827 - 837] Pages: 11

DOI: 10.2174/138620709789383268

Price: $65

Abstract

Efficiency and accuracy in addressing drug safety issues proactively are critical in minimizing late-stage drug attritions. Discovery Toxicology has become a specialty subdivision of Toxicology seeking to effectively provide early predictions and safety assessment in the drug discovery process. Among the many technologies utilized to select safer compounds for further development, in vitro imaging technology is one of the best characterized and validated to provide translatable biomarkers towards clinically-relevant outcomes of drug safety. By carefully applying imaging technologies in genetic, hepatic, and cardiac toxicology, and integrating them with the rest of the drug discovery processes, it was possible to demonstrate significant impact of imaging technology on drug research and development and substantial returns on investment.

Keywords: Translational medicine, lead optimization, genetic toxicology, hepatotoxicity, cardiac safety screens, Ames, micronucleus, idiosyncratic drug induced liver injury, phospholipidosis, and cardiotoxicity test


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