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Current Clinical Pharmacology


ISSN (Print): 1574-8847
ISSN (Online): 2212-3938

Molecular Determinants of Fluoroquinolone Antibacterial Agents Pharmacokinetics

Author(s): Dominique Leveque and Francois Jehl

Volume 4, Issue 3, 2009

Page: [191 - 197] Pages: 7

DOI: 10.2174/157488409789375348

Price: $65


This review presents the published data regarding the molecular determinants (enzymes, transporters, orphan nuclear receptors) of fluoroquinolones pharmacokinetics in humans. The clinical impact of these determinants (drug disposition, drug-drug interactions) is also discussed.

Keywords: Fluoroquinolone, ciprofloxacin, ofloxacin, levofloxacin, moxifloxacin, pharmacokinetics, enzymes, drug transporters

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