Abstract
The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-inwater emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated to be a function of the charge and concentration of the initial emulsion stabiliser; charge and initial loading phase of nanoparticles and physicochemical properties of the drug molecule. The improved physical stability of the emulsions and the chemical stability of two model lipophilic agents (all-trans-retinol and acridine orange 10-nonyl bromide) confirmed that engineered nanoparticle layers can enhance the shelf-life of liable lipophilic agents. Nanoparticle coatings are shown to control the in-vitro release of active agents from emulsions and significantly promote skin retention. The lipophilic agents distributed into the deeper viable skin layers without permeation through full-thickness skin and hence systemic exposure. Nanoparticle-coated submicron oil-in-water emulsions can serve as novel dermal carriers with controlled release kinetics and targeted drug delivery.
Keywords: Submicron emulsions, silica nanoparticles, chemical stability, in-vitro release, dermal delivery, skin retention/permeation
Current Drug Delivery
Title: Nanoparticle Coated Emulsions as Novel Dermal Delivery Vehicles
Volume: 6 Issue: 4
Author(s): Nasrin Ghouchi Eskandar, Spomenka Simovic and Clive A. Prestidge
Affiliation:
Keywords: Submicron emulsions, silica nanoparticles, chemical stability, in-vitro release, dermal delivery, skin retention/permeation
Abstract: The dermal delivery characteristics of hydrophilic silica nanoparticle coated medium chain triglyceride oil-inwater emulsions are reported and correlated with the physicochemical and interfacial properties of the emulsion based drug carriers. The synergistic drug/stabiliser/nanoparticle interactions are demonstrated to be a function of the charge and concentration of the initial emulsion stabiliser; charge and initial loading phase of nanoparticles and physicochemical properties of the drug molecule. The improved physical stability of the emulsions and the chemical stability of two model lipophilic agents (all-trans-retinol and acridine orange 10-nonyl bromide) confirmed that engineered nanoparticle layers can enhance the shelf-life of liable lipophilic agents. Nanoparticle coatings are shown to control the in-vitro release of active agents from emulsions and significantly promote skin retention. The lipophilic agents distributed into the deeper viable skin layers without permeation through full-thickness skin and hence systemic exposure. Nanoparticle-coated submicron oil-in-water emulsions can serve as novel dermal carriers with controlled release kinetics and targeted drug delivery.
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Cite this article as:
Eskandar Ghouchi Nasrin, Simovic Spomenka and Prestidge A. Clive, Nanoparticle Coated Emulsions as Novel Dermal Delivery Vehicles, Current Drug Delivery 2009; 6 (4) . https://dx.doi.org/10.2174/156720109789000456
DOI https://dx.doi.org/10.2174/156720109789000456 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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