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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Combination of MafA, PDX-1 and NeuroD is a Useful Tool to Efficiently Induce Insulin-Producing Surrogate β -Cells

Author(s): Hideaki Kaneto, Taka-aki Matsuoka, Naoto Katakami and Munehide Matsuhisa

Volume 16 , Issue 24 , 2009

Page: [3144 - 3151] Pages: 8

DOI: 10.2174/092986709788802980

Price: $65

Abstract

A decrease in the number of functioning pancreatic β-cells and insufficient insulin biosynthesis and/or secretion are the hallmarks of diabetes. Therefore, the identification of alternative sources to induce insulin-producing surrogate β-cells is of great importance. For the induction of insulin-producing cells from various cells and/or tissues, it is useful to mimic and reproduce expression alterations of various pancreatic transcription factors observed during normal pancreas development and to induce key pancreatic transcription factors which have the potency to induce insulin and other β-cell-related genes. MafA, PDX-1 and NeuroD directly bind to the insulin gene promoter and function as very important transcription factors in pancreatic β-cell differentiation and mature β-cell function. The combination of MafA, PDX-1 and NeuroD markedly induces insulin biosynthesis in various non-β-cells and thereby is a useful tool to efficiently induce insulin- producing surrogate β-cells.

Keywords: MafA, PDX-1, NeuroD, β-cell differentiation, surrogate β-cells


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