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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

New Therapeutic Targets for Drug Design Against Trypanosoma cruzi, Advances and Perspectives

Author(s): Gildardo Rivera, Virgilio Bocanegra-Garcia, Cynthia Ordaz-Pichardo, Benjamin Nogueda-Torres and Antonio Monge

Volume 16 , Issue 25 , 2009

Page: [3286 - 3293] Pages: 8

DOI: 10.2174/092986709788803303

Price: $65

Abstract

Chagas disease is one of the most important parasitic diseases in Latin America, affecting16 to 18 million people. Nifurtimox and Benznidazol are drugs that are commonly used in its treatment; however, these drugs produce several adverse reactions and are not effective in the chronic phase of the disease. Therefore, the design, synthesis, and biological evaluation of new compounds with potential activity against Trypanozoma cruzi are of great importance. We review six proteins involved in the biochemical metabolism of Trypanosoma cruzi that have recently been studied as potential targets for designing new drugs for Chagas disease. These are farnesyl pyrophosphate synthase, trans-sialidase, cruzain cystein protease, trypanothione reductase, glucose 6-phosphate-dehydrogenase, glyceraldehyde 3-phosphatedehydrogenase, and α-hydroxy acid dehydrogenase. We also review the advances of compounds recently designed based on structure-activity, and the perspectives of new compounds that inhibit these therapeutic targets.

Keywords: Chagas disease, Trypanosoma cruzi, therapeutic targets, drug design


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