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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

2-Arylbenzothiazole as a Privileged Scaffold in Drug Discovery

Author(s): A. A. Weekes and A. D. Westwell

Volume 16 , Issue 19 , 2009

Page: [2430 - 2440] Pages: 11

DOI: 10.2174/092986709788682137

Price: $65


Substituted 2-arylbenzothiazoles have emerged in recent years as an important pharmacophore in a number of diagnostic and therapeutic settings. Attractive features of drug candidates based on this benzothiazole scaffold include their synthetic accessibility, and synthetic approaches to 2-arylbenzothiazole-based compounds will be reviewed here. Examples of 2-arylbenzothiazoles endowed with diagnostic/therapeutic activity include the 2-(4-aminophenyl)benzothiazole series, which has a remarkable activity profile in both the potential non-invasive diagnosis of Alzheimers disease and as antitumour agents.

Keywords: 2-Arylbenzothiazoles, synthesis, Alzheimer's disease diagnosis, positron emission tomography, antitumour agents

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