Function and Antagonism of β Integrins in the Development of Cancer Therapy

H.   M.   Sheldrake; L.   H.   Patterson

Abstract

The integrin family of cell surface receptors integrates cell-extracellular matrix interactions with the cell cytoskeleton and signalling across the cell membrane, resulting in an important role in cell adhesion, mobility and migration, proliferation, and survival. Changes in the number and identity of integrin receptors are common in cancer cells resulting in alteration of the ability of malignant cells to interact with the extracellular matrix, and promoting migration as well as facilitating survival outside the tumour normal environment. β integrins are potentially involved in every step of the metastatic process and expression of both αρ β and α β is correlated with metastatic ability of tumour cells. The recognition of the RGD binding motif common to the disintegrins and natural integrin ligands such as fibrinogen allowed the development of small molecule β integrin antagonists, progressing from linear peptides containing the RGD sequence to cyclic peptides with well-defined conformation, and hence to small molecule peptidomimetics with improved pharmacological properties. In this review, we summarize the role of the β -subfamily of integrins when expressed in normal and tumour tissue, the development of small-molecule antagonists of β integrins and their potential anti-cancer applications.

Keywords: β, integrin, cancer, metastasis, RGD peptidomimetic

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