Abstract
The INhibitor of Growth (ING) genes were discovered during the past decade and identified as type II tumor suppressor genes. Previous studies demonstrated that ING family members participate in various cellular stress responses and thus play important roles in the pathogenesis of various types of cancers, including melanoma. Epidemiological studies showed that UV radiation is the primary etiological factor in melanoma development. Here we review the studies on the role of ING proteins in cellular responses to UV irradiation, melanoma cell motility, and melanoma progression.
Keywords: ING, tumor suppressor, melanoma, UV irradiation, stress response
Current Drug Targets
Title: The Role of ING Tumor Suppressors in UV Stress Response and Melanoma Progression
Volume: 10 Issue: 5
Author(s): Jun Li, Yemin Wang, Ronald P.C. Wong and Gang Li
Affiliation:
Keywords: ING, tumor suppressor, melanoma, UV irradiation, stress response
Abstract: The INhibitor of Growth (ING) genes were discovered during the past decade and identified as type II tumor suppressor genes. Previous studies demonstrated that ING family members participate in various cellular stress responses and thus play important roles in the pathogenesis of various types of cancers, including melanoma. Epidemiological studies showed that UV radiation is the primary etiological factor in melanoma development. Here we review the studies on the role of ING proteins in cellular responses to UV irradiation, melanoma cell motility, and melanoma progression.
Export Options
About this article
Cite this article as:
Li Jun, Wang Yemin, Wong P.C. Ronald and Li Gang, The Role of ING Tumor Suppressors in UV Stress Response and Melanoma Progression, Current Drug Targets 2009; 10 (5) . https://dx.doi.org/10.2174/138945009788185031
DOI https://dx.doi.org/10.2174/138945009788185031 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Cancer, Signal Transduction and Nanotechnology
Current Drug Delivery Pityriasis Rosea: An Updated Review
Current Pediatric Reviews Patent Selections
Recent Patents on Anti-Infective Drug Discovery The Medical Potential of Antimicrobial Peptides from Insects
Current Topics in Medicinal Chemistry Placental Drug Transporters
Current Drug Metabolism Synthesis and Antitumoral Evaluation of Benzyl (1S)-2-[2-(monosubstituted-benzylidene)hydrazino]-1-(hydroxymethyl)-2-oxoethylcarbamate
Letters in Drug Design & Discovery Polyunsaturated Fatty Acids in Pregnancy and Metabolic Syndrome: A Review
Current Pharmaceutical Biotechnology Berberine Interfered with Breast Cancer Cells Metabolism, Balancing Energy Homeostasis
Anti-Cancer Agents in Medicinal Chemistry Edelfosine in Membrane Environment - the Langmuir Monolayer Studies
Anti-Cancer Agents in Medicinal Chemistry Anti-Cancer / Anti-Tumor
Current Bioactive Compounds Gene Therapy: Optimising DNA Delivery to the Nucleus
Current Drug Targets A3 Receptor Ligands: Past, Present and Future Trends
Current Topics in Medicinal Chemistry RNA Binding Protein/RNA Element Interactions and the Control of Translation
Current Protein & Peptide Science Molecular Targeting of Lymphatics for Therapy
Current Pharmaceutical Design Effects of Natural Compounds on Xenopus Embryogenesis: A Potential Read Out for Functional Drug Discovery Targeting Wnt/β-catenin Signaling
Current Topics in Medicinal Chemistry Progress in the Synthesis of 2,3-unsaturated Glycosides
Current Organic Chemistry Clinical Considerations of Focal Drug Delivery in Cancer Treatment
Current Drug Delivery Molecular Cloning of a Novel PPEF-1 Gene Variant from a T-Cell Lymphoblastic Lymphoma Cell Line
Recent Patents on DNA & Gene Sequences Plumbagin Inhibits Breast Tumor Bone Metastasis and Osteolysis by Modulating the Tumor-Bone Microenvironment
Current Molecular Medicine The Anti-Breast Cancer Effects of Green-Synthesized Zinc Oxide Nanoparticles Using Carob Extracts
Anti-Cancer Agents in Medicinal Chemistry