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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

The Role of Gut Microbiota in Drug Response

Author(s): I. D. Wilson and J. K. Nicholson

Volume 15, Issue 13, 2009

Page: [1519 - 1523] Pages: 5

DOI: 10.2174/138161209788168173

Price: $65


Higher organisms such as mammals exist in a symbiotic relationship with their gut microbiota, formed from a diverse and highly metabolically active consortium of species. The gut microbiota, in addition to their ability to process dietary derived material, are also capable of performing a range of biotransformations on xenobiotics, such as drugs and their metabolites, in ways that can affect absorption and bioavailability. The potential for the gut microflora to influence drug metabolism and toxicity in unexpected ways is discussed.

Keywords: Drug metabolism, bioavailability, gut microbiota, superorganisms, population differences, diet

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