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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Pharmacological Implications of MMP-9 Inhibition by ACE Inhibitors

Author(s): Daisuke Yamamoto and Shinji Takai

Volume 16 , Issue 11 , 2009

Page: [1349 - 1354] Pages: 6

DOI: 10.2174/092986709787846514

Price: $65

Abstract

Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.

Keywords: Matrix metalloproteinase-9, angiotensin converting enzyme inhibitor, angiotensin II receptor blocker, myocardial infarction, cardiovascular protection, coronary diseases, molecular interaction, inhibitory specificity


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