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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Iron Oxide Nanoparticle Platform for Biomedical Applications

Author(s): J. Xie, J. Huang, X. Li, S. Sun and X. Chen

Volume 16 , Issue 10 , 2009

Page: [1278 - 1294] Pages: 17

DOI: 10.2174/092986709787846604

Price: $65

Abstract

Progress in nanosynthesis has succeeded in making nanoscale particles from iron oxide under precise quality control. Given the recent great advances in polymer manufacturing, antibody purification, DNA/RNA synthesis and magnetic resonance imaging (MRI), such iron oxide nanoparticles (IONPs) have been enriched with many variables and attracted great interest in studying their potential biomedical applications. After nearly two decades ’ effort, IONPs have become a powerful platform in many diverse aspects of biomedicine, including MRI, gene and drug delivery, and hyperthermia. While some studies are still at the proof-of-concept stage, others have now been widely used in clinics. With the on-going efforts to enhance their targeting ability and endow more functions, IONPs future applications are highly expected.

Keywords: Iron oxide nanoparticles, magnetic resonance imaging, multimodality, surface modification, drug delivery, pharmacokinetics


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