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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Mitochondrial Respiratory Complex I: Structure, Function and Implication in Human Diseases

Author(s): Lokendra K. Sharma, Jianxin Lu and Yidong Bai

Volume 16, Issue 10, 2009

Page: [1266 - 1277] Pages: 12

DOI: 10.2174/092986709787846578

Price: $65


Mitochondria are ubiquitous organelles in eukaryotic cells whose primary function is to generate energy supplies in the form of ATP through oxidative phosphorylation. As the entry point for most electrons into the respiratory chain, NADH:ubiquinone oxidoreductase, or complex I, is the largest and least understood component of the mitochondrial oxidative phosphorylation system. Substantial progress has been made in recent years in understanding its subunit composition, its assembly, the interaction among complex I and other respiratory components, and its role in oxidative stress and apoptosis. This review provides an updated overview of the structure of complex I, as well as its cellular functions, and discusses the implication of complex I dysfunction in various human diseases.

Keywords: Mitochondria, complex I, oxidative stress, reactive oxygen species, apoptosis, complex I functions

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