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Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Metal Complexes, their Cellular Targets and Potential for Cancer Therapy

Author(s): Di Chen, Vesna Milacic, Michael Frezza and Q. Ping Dou

Volume 15, Issue 7, 2009

Page: [777 - 791] Pages: 15

DOI: 10.2174/138161209787582183

Price: $65

Abstract

The development of metal complexes with anticancer activity has had an enormous impact on cancer chemotherapy. The discovery of cisplatin in the 1960s represented a landmark achievement and ushered in a new era in cancer treatment. Despite the fact that cisplatin has achieved significant clinical benefit for several types of solid tumors, its effectiveness has been hampered by toxic side effects and tumor resistance that often leads to the occurrence of secondary malignancies. However, discovery and use of cisplatin have encouraged investigators to search for and develop novel non platinum-containing metal species with superior anti-cancer activity and low side effects. As examples, gallium salts and gold complexes have been evaluated in phase I and phase II trials. Copper-chelating compounds have also shown promising results in both preclinical and clinical studies. This review provides a comprehensive overview of various non platinum metal complexes and metal-chelating compounds and discusses their potential molecular targets in tumor cells and their applications in cancer therapy.

Keywords: Metal complexes, copper-binding compounds, gold complexes, gallium, proteasome inhibitors, anticancer drugs, apoptosis


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