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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Ascorbic Acid in Postoperative Intensive Care Patients - Biochemical Aspects and Clinical Experience

Author(s): Andreas Rumelin

Volume 16 , Issue 2 , 2009

Page: [184 - 188] Pages: 5

DOI: 10.2174/092986709787002781

Price: $65


The transport mechanisms of ascorbic acid (AA) are described. The metabolism of AA and its function as an antioxidant are covered in some detail. Subsequently, indications for postoperative substitution are discussed. The supplementation of up to 300 mg of AA per day in postoperative intensive care unit patients during par-/enteral nutrition is recommended to prevent hypovitaminosis. It is not clear if this is the optimal dosage of AA in postoperative/-trauma patients. New aspects for an AA substitution are discussed.

Keywords: Vitamin C, ascorbic acid, intensive care, ICU, metabolism, trauma, operation

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