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Current Drug Metabolism


ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

Use of Nano-Electrospray for Metabolite Identification and QuantitativeAbsorption, Distribution, Metabolism and Excretion Studies

Author(s): Cornelis E.C.A. Hop

Volume 7, Issue 5, 2006

Page: [557 - 563] Pages: 7

DOI: 10.2174/138920006777697909

Price: $65


Determination of the pharmacokinetics and metabolite identification have been an integral part of drug discov-ery and development to ensure that drugs have appropriate absorption, distribution, metabolism and excretion properties.Liquid chromatography interfaced with a mass spectrometer has greatly facilitated these studies. Nano-electrospray hasdistinct sensitivity advantages and the increased amount of time available to perform mass spectrometric experiments fa-cilitates structural characterization of metabolites. The recently developed silicon chip-based nano-electrospray devicesare more practical than pulled capillaries. The use of these devices for the determination of pharmacokinetics and metabo-lite identification will be described and particular attention will be paid to the distinct advantages and disadvantages thesedevices offer.

Keywords: ADME, LC-MS/MS, metabolite identification, nano-electrospray, drug metabolism

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