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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Perspective

Is Curcumin a Safe and Effective Therapeutic in the Treatment against Oral Lichen Planus?

Author(s): Motahareh Khosrojerdi, Eric Gumpricht, Tannaz Jamialahmadi, Prashant Kesharwani and Amirhossein Sahebkar*

Volume 30, Issue 15, 2023

Published on: 23 December, 2022

Page: [1684 - 1688] Pages: 5

DOI: 10.2174/0929867330666221202150727

Abstract

Oral lichen planus (OLP) is a chronic mucocutaneous, immunological disease that occurs more frequently in the buccal mucosa of middle-aged female patients. OLP's standard treatment is topical or systemic corticosteroids. Due to corticosteroids’ numerous potential side effects, there is an effort to find an alternative treatment. One alternative treatment is curcumin. Several studies have investigated the effectiveness and safety of curcumin in OLP patients. In this review, we summarized the literature focusing on the effectiveness and safety of curcumin in OLP patients. Our review of clinical trials revealed that either 6000 mg/day curcumin, 80 mg/day nano-curcumin, or 1% curcumin oral gel 6 times/day offered benefits in the treatment of OLP.

Keywords: Oral lichen planus, curcumin, phytomedicine, immunological disease, buccal mucosa, corticosteroids.

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