Abstract
The sulfonamides constitute an important class of drugs, which display a variety of activities including antibacterial, anticarbonic anhydrase, diuretic, hypoglycemic and antithyroid effectiveness. A number of sulfonamides have been reported to be potent anticancer agents, which interact with a wide range of different cellular targets. Among these interesting sulfonamides, the diaryl or heterocyclic sulfonamides have recently emerged as an important class of antimitotic agents against different types of cancer, including multidrug resistant tumors. This review summarizes the recent advances of the diaryl or heterocyclic sulfonamides as novel antimitotic agents.
Keywords: Antimitotic Agents, Heterocyclic Sulfonamides, anticarbonic anhydrase, hypoglycemic, potent anticancer agents, tumor cell, structure-activity relationships (SAR)
Anti-Cancer Agents in Medicinal Chemistry
Title: Novel Diaryl or Heterocyclic Sulfonamides as Antimitotic Agents
Volume: 8 Issue: 7
Author(s): Laixing Hu, Zhuo-rong Li, Jian-dong Jiang and David W. Boykin
Affiliation:
Keywords: Antimitotic Agents, Heterocyclic Sulfonamides, anticarbonic anhydrase, hypoglycemic, potent anticancer agents, tumor cell, structure-activity relationships (SAR)
Abstract: The sulfonamides constitute an important class of drugs, which display a variety of activities including antibacterial, anticarbonic anhydrase, diuretic, hypoglycemic and antithyroid effectiveness. A number of sulfonamides have been reported to be potent anticancer agents, which interact with a wide range of different cellular targets. Among these interesting sulfonamides, the diaryl or heterocyclic sulfonamides have recently emerged as an important class of antimitotic agents against different types of cancer, including multidrug resistant tumors. This review summarizes the recent advances of the diaryl or heterocyclic sulfonamides as novel antimitotic agents.
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Cite this article as:
Hu Laixing, Li Zhuo-rong, Jiang Jian-dong and Boykin W. David, Novel Diaryl or Heterocyclic Sulfonamides as Antimitotic Agents, Anti-Cancer Agents in Medicinal Chemistry 2008; 8 (7) . https://dx.doi.org/10.2174/187152008785914806
DOI https://dx.doi.org/10.2174/187152008785914806 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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