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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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General Review Article

Dietary Flavonoids and Adult Neurogenesis: Potential Implications for Brain Aging

Author(s): Sergio Davinelli*, Alessandro Medoro, Sawan Ali, Daniela Passarella, Mariano Intrieri and Giovanni Scapagnini

Volume 21, Issue 3, 2023

Published on: 03 November, 2022

Page: [651 - 668] Pages: 18

DOI: 10.2174/1570159X21666221031103909

Price: $65

Abstract

Adult neurogenesis deficiency has been proposed to be a common hallmark in different age-related neurodegenerative diseases. The administration of flavonoids is currently reported as a potentially beneficial strategy for preventing brain aging alterations, including adult neurogenesis decline. Flavonoids are a class of plant-derived dietary polyphenols that have drawn attention for their neuroprotective and pro-cognitive effects. Although they undergo extensive metabolism and localize in the brain at low concentrations, flavonoids are now believed to improve cerebral vasculature and interact with signal transduction cascades involved in the regulation of adult neurogenesis. Furthermore, many dietary flavonoids have been shown to reduce oxidative stress and neuroinflammation, improving the neuronal microenvironment where adult neurogenesis occurs. The overall goal of this review is to summarize the evidence supporting the role of flavonoids in modulating adult neurogenesis as well as to highlight how these dietary agents may be promising candidates in restoring healthy brain function during physiological and pathological aging.

Keywords: Flavonoids, diet, aging, brain, adult neurogenesis, neurodegeneration.

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