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Perspective

Long Non-coding RNA Therapeutics: Recent Advances and Challenges

Author(s): Anjali Sangeeth, Mahesh Malleswarapu, Amit Mishra and Ravi Kumar Gutti*

Volume 23, Issue 16, 2022

Published on: 10 October, 2022

Page: [1457 - 1464] Pages: 8

DOI: 10.2174/1389450123666220919122520

Abstract

The discovery of the roles of RNA other than just as a messenger, such as a ribozyme, and regulatory RNAs, such as microRNA and long noncoding RNAs, is fascinating. RNA is now recognized as an important regulator involved in practically every biological process. Research in the field of non-coding RNAs, specifically microRNAs (miRNAs) and long non-coding RNAs (LncRNAs) have developed immensely over the years. Recent studies identified diverse RNAs, including non-coding RNAs such as LncRNA and their various modes of action in the cells. These RNAs are anticipated to be key targets for the treatment of various diseases since they control a broad array of biological pathways. LncRNA-targeted drug platform delivers the pharmaceutical industry a myriad of opportunities and has the potential to modulate diseases at the genetic level while also overcoming the limitations of inconsistent proteins. This article focuses on the recent advancement as well as the major challenges in the field and describes the various RNA-based therapeutics that alter the quality of healthcare for many diseases and bring personalized medicines to fruition. The article also summarizes RNA-based therapeutics that are undergoing testing in clinical trials or have been granted FDA approval.

Keywords: miRNAs, lncRNAs, circRNAs, AML, CML, ribozyme.

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