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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Mini-Review Article

LncRNA DSCAM-AS1: A Pivotal Therapeutic Target in Cancer

Author(s): Chengyu Hu*

Volume 23, Issue 5, 2023

Published on: 03 October, 2022

Page: [530 - 536] Pages: 7

DOI: 10.2174/1389557522666220822121935

Price: $65

Abstract

Background: LncRNAs are an emerging category of non-coding RNAs. LncRNAs are usually greater than 200 nucleotides in length and do not possess protein editing capabilities. DSCAM-AS1 is a highly valued member of the lncRNAs family. Numerous studies have revealed the involvement of the oncogene DSCAM-AS1 in multiple biological processes, including metastasis, aggressiveness and cell proliferation. This review discusses the molecular mechanisms and clinical significance of DSCAM-AS1 in various tumor types.

Methods: This paper analyzes and summarizes current research by searching PubMed using “DSCAM-AS1” and “tumor” as keywords.

Results: DSCAM-AS1 is a valuable tumor-associated lncRNA with significant oncogenic effects. It is abnormally expressed in a variety of cancers, such as non-small cell lung cancer, cervical cancer, osteosarcoma, colorectal cancer, breast cancer, gastric cancer and endometrial cancer. The overexpression of DSCAM-AS1 promotes cancer progression by modulating cancer cell proliferation, invasion, distant metastasis, and resistance.

Conclusion: DSCAM-AS1 is upregulated and acts as an oncogene in multiple tumors. As more systematic studies are performed, DSCAM-AS1 may prove to be a promising therapeutic target or tumor biomarker.

Keywords: Long noncoding RNA, DSCAM-AS1, tumorigenesis, tumor biomarker, therapeutic target, molecular mechanisms, oncogene.

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