Abstract
Enzymes are widely recognized as valuable tools for the synthesis of optically active compounds. Thus, lipasecatalysed acylation or deacylation are one of the most efficient methods for the preparation of optically active alcohols, acids and esters. In addition, other nitrogenated organic compounds can also be prepared through enzymatic aminolysis or ammonolysis reactions. Amines and their derived amides are important compounds in organic synthesis, because of the presence of theses functions in many pharmacologically active compounds. On the other hand, enantiopure amines are used in the fine chemical industry as resolving agents, chiral auxiliaries and their preparation by enzymatic acylation of amines is nowadays a well established methodology. In addition, in the last few years, many companies, especially from the pharmaceutical industry, use enzymatic aminolysis and ammonolysis processes for the preparation of enantiopure amines in a multigram scale.
Keywords: Enantioselective enzymatic desymmetrizations (EEDs), Candida antarctica B, Chemoselective Processes, Acyl Donors, Primary Monoamines, alkoxycarbonylation
Current Organic Chemistry
Title: Enzymatic Aminolysis and Ammonolysis Processes in the Preparation of Chiral Nitrogenated Compounds
Volume: 10 Issue: 10
Author(s): Vicente Gotor-Fernandez and Vicente Gotor
Affiliation:
Keywords: Enantioselective enzymatic desymmetrizations (EEDs), Candida antarctica B, Chemoselective Processes, Acyl Donors, Primary Monoamines, alkoxycarbonylation
Abstract: Enzymes are widely recognized as valuable tools for the synthesis of optically active compounds. Thus, lipasecatalysed acylation or deacylation are one of the most efficient methods for the preparation of optically active alcohols, acids and esters. In addition, other nitrogenated organic compounds can also be prepared through enzymatic aminolysis or ammonolysis reactions. Amines and their derived amides are important compounds in organic synthesis, because of the presence of theses functions in many pharmacologically active compounds. On the other hand, enantiopure amines are used in the fine chemical industry as resolving agents, chiral auxiliaries and their preparation by enzymatic acylation of amines is nowadays a well established methodology. In addition, in the last few years, many companies, especially from the pharmaceutical industry, use enzymatic aminolysis and ammonolysis processes for the preparation of enantiopure amines in a multigram scale.
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Cite this article as:
Gotor-Fernandez Vicente and Gotor Vicente, Enzymatic Aminolysis and Ammonolysis Processes in the Preparation of Chiral Nitrogenated Compounds, Current Organic Chemistry 2006; 10 (10) . https://dx.doi.org/10.2174/138527206777698084
DOI https://dx.doi.org/10.2174/138527206777698084 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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