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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Case Report

Antipsychotics Induced Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome: Literature Review and a Report of a Suspected Case Related to Chlorpromazine

Author(s): Lakhoua Ghozlane*, Jerbi Asma, Zaiem Ahmed, Charfi Ons, Kastalli Sarrah, Dhaghfous Riadh and El Aidli Sihem

Volume 18, Issue 4, 2023

Published on: 29 August, 2022

Page: [571 - 575] Pages: 5

DOI: 10.2174/1574886317666220603104837

Price: $65

Abstract

Introduction/background: Drug reaction with eosinophilia and systemic symptoms reaction (DRESS) syndrome is a serious, potentially life-threatening drug side effect associated with more and more drugs. However, antipsychotics have rarely been involved in such condition.

Case Report: We report here a suspected case of chlorpromazine induced DRESS syndrome in a 33-year-old woman with a history of allergic rhinitis and bipolar disorder who has reported an unexplored generalized skin eruption after taking chlorpromazine 10 years before.

Only 24 hours after starting the therapy, the patient developed erythematous skin eruption on her limbs and her trunk with biological abnormalities, including liver enzyme elevation and eosinophilia.

Skin eruption disappeared spontaneously within 3 days after therapy discontinuation and subsequently, biological abnormalities regressed. Patch tests were performed and were positive for chlorpromazine. At same time, we performed a literature review of the DRESS syndrome induced by antipsychotics. No patch tests were performed for those cases.

Conclusion: Clinicians should be aware of such clinical features after starting patients on antipsychotics to withdraw the culprit drug as early as possible and avoid further complications.

Keywords: Dress syndrome, antipsychotics, chlorpromazine, psychopharmacology, allergic rhinitis, patch test.

« Previous Next »
[1]
Gowda SM, Vijay Kumar KG, Shilpa K. Chlorpromazine-induced drug reaction with eosinophilia and systemic symptoms syndrome. Indian J Psychol Med 2020; 42(1): 99-101.
[http://dx.doi.org/10.4103/IJPSYM.IJPSYM_364_19] [PMID: 31997872]
[2]
Bommersbach TJ, Lapid MI, Leung JG, Cunningham JL, Rummans TA, Kung S. Management of psychotropic drug-induced DRESS syndrome: A systematic review. Mayo Clin Proc 2016; 91(6): 787-801.
[http://dx.doi.org/10.1016/j.mayocp.2016.03.006] [PMID: 27126302]
[3]
Kardaun SH, Sidoroff A, Valeyrie-Allanore L, et al. Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: Does a DRESS syndrome really exist? Br J Dermatol 2007; 156(3): 609-11.
[http://dx.doi.org/10.1111/j.1365-2133.2006.07704.x] [PMID: 17300272]
[4]
Shiohara T, Mizukawa Y. Drug-induced Hypersensitivity Syndrome (DiHS)/Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): An update in 2019. Allergol Int 2019; 68(3): 301-8.
[http://dx.doi.org/10.1016/j.alit.2019.03.006] [PMID: 31000444]
[5]
Moore N, Berdaï D, Blin P, Droz C. Pharmacovigilance - The next chapter. Therapies 2019; 74(6): 557-67.
[http://dx.doi.org/10.1016/j.therap.2019.09.004] [PMID: 31623850]
[6]
Martínez-Cabriales SA, Rodríguez-Bolaños F, Shear NH. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): How far have we come? Am J Clin Dermatol 2019; 20(2): 217-36.
[http://dx.doi.org/10.1007/s40257-018-00416-4] [PMID: 30652265]
[7]
Behera SK, Das S, Xavier AS, Selvarajan S. DRESS syndrome: A detailed insight. Hosp Pract 2018; 46(3): 152-62.
[http://dx.doi.org/10.1080/21548331.2018.1451205] [PMID: 29519170]
[8]
Taleb S, Zgueb Y, Ouali U, Jomli R, Kort Y, Nacef F. Drug reaction with eosinophilia and systemic symptoms syndrome related to aripiprazole therapy. J Clin Psychopharmacol 2019; 39(6): 691-3.
[http://dx.doi.org/10.1097/JCP.0000000000001138] [PMID: 31688404]
[9]
Ben-Ari K, Goldberg I, Shirazi I, et al. An unusual case of DRESS syndrome. Journal of dermatological case reports 2008; 2(3): 39-42.
[http://dx.doi.org/10.3315/jdcr.2008.1016]
[10]
Hassine H, Ouali U, Ouertani A, Jomli R, Nacef F. Clozapine-induced DRESS syndrome with multiple and rare organ involvement. Asian J Psychiatr 2017; 28: 146-7.
[http://dx.doi.org/10.1016/j.ajp.2017.04.013] [PMID: 28784369]
[11]
Moazez C, Rudha Y, Narang N, Younger T. A rare presentation of clozapine-induced DRESS syndrome. Case Rep Med 2018; 2018: 1346351.
[http://dx.doi.org/10.1155/2018/1346351] [PMID: 29991947]
[12]
Sanader B, Grohmann R, Grötsch P, et al. Clozapine-induced DRESS syndrome: A case series from the AMSP multicenter drug safety surveillance project. Pharmacopsychiatry 2019; 52(3): 156-9.
[http://dx.doi.org/10.1055/a-0586-8983] [PMID: 29554696]
[13]
Raz A, Bergman R, Eilam O, Yungerman T, Hayek T. A case report of olanzapine-induced hypersensitivity syndrome. Am J Med Sci 2001; 321(2): 156-8.
[http://dx.doi.org/10.1097/00000441-200102000-00008] [PMID: 11217818]
[14]
Su HH, Hsu CC, Fang CK. Suspected Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) secondary to quetiapine in an elderly patient. Int J Gerontol 2014; 8(1): 45.
[http://dx.doi.org/10.1016/j.ijge.2013.07.001]
[15]
Tsai CF, Tsai SJ, Hwang JP. Ziprasidone-induced hypersensitivity syndrome in an aged schizophrenia patient. Int J Geriatr Psychiatry 2005; 20(8): 797-9.
[http://dx.doi.org/10.1002/gps.1346] [PMID: 16035110]
[16]
Kim MS, Kim SW, Han TY, Son SJ, Lee JH, Kim EJ. Ziprasidone-induced hypersensitivity syndrome confirmed by reintroduction. Int J Dermatol 2014; 53(4): e267-8.
[http://dx.doi.org/10.1111/ijd.12246] [PMID: 24117439]
[17]
Lister JF, Voinov B, Thimothy L, Bean JR. Drug-induced systemic hypersensitivity reaction associated with ziprasidone: An atypical occurrence. J Clin Psychopharmacol 2015; 35(4): 478-80.
[http://dx.doi.org/10.1097/JCP.0000000000000364] [PMID: 26120944]
[18]
Barbaud A, Collet E, Milpied B, et al. A multicentre study to determine the value and safety of drug patch tests for the three main classes of severe cutaneous adverse drug reactions. Br J Dermatol 2013; 168(3): 555-62.
[http://dx.doi.org/10.1111/bjd.12125] [PMID: 23136927]
[19]
Husain Z, Reddy BY, Schwartz RA. DRESS syndrome. J Am Acad Dermatol 2013; 68(5): 709.e1-9.
[http://dx.doi.org/10.1016/j.jaad.2013.01.032]

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