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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

Review Article

Association of Nutrients, Specific Dietary Patterns, and Probiotics with Age-related Macular Degeneration

Author(s): Yanqun Cao, Yuli Li, Antonia Gkerdi, James Reilly, Zhoujin Tan and Xinhua Shu*

Volume 29, Issue 40, 2022

Published on: 12 September, 2022

Page: [6141 - 6158] Pages: 18

DOI: 10.2174/0929867329666220511142817

Price: $65

Abstract

Age-related macular degeneration (AMD) is a complex disease that mainly affects people over 50 years of age. Even though management of the vascularisation associated with the “wet” form of AMD is effective using anti-VEGF drugs, there is currently no treatment for the “dry” form of AMD. Given this, it is imperative to develop methods for disease prevention and treatment. For this review, we searched scientific articles via PubMed and Google Scholar, and considered the impact of nutrients, specific dietary patterns, and probiotics on the incidence and progression of AMD. Many studies revealed that regular consumption of foods that contain ω-3 fatty acids is associated with a lower risk for late AMD. Particular dietary patterns, such as the Mediterranean diet that contains ω-3 FAs-rich foods (nuts, olive oil, and fish), seem to be protective against AMD progression compared to Western diets that are rich in fats and carbohydrates. Furthermore, randomized controlled trials that investigated the role of nutrient supplementation in AMD have shown that treatment with antioxidants, such as lutein/zeaxanthin, zinc, and carotenoids, may be effective against AMD progression. More recent studies have investigated the association of the antioxidant properties of gut bacteria, such as Bacteroides and Eysipelotrichi, with lower AMD risk in individuals whose microbiota is enriched with them. These are promising fields of research that may yield the capacity to improve the quality of life for millions of people, allowing them to live with a clear vision for longer and avoiding the high cost of vision-saving surgery.

Keywords: Retina, retinal pigment epithelium, dietary habits, nutrition, food intake, age-related macular degeneration.

[1]
Cruickshanks, K.J.; Hamman, R.F.; Klein, R.; Nondahl, D.M.; Shetterly, S.M. The colorado-wisconsin study of age-related maculopathy. The prevalence of age-related maculopathy by geographic region and ethnicity. Arch. Ophthalmol., 1997, 115(2), 242-250.
[http://dx.doi.org/10.1001/archopht.1997.01100150244015] [PMID: 9046260]
[2]
Li, J.Q.; Welchowski, T.; Schmid, M.; Mauschitz, M.M.; Holz, F.G.; Finger, R.P. Prevalence and incidence of age-related macular degeneration in Europe: A systematic review and meta-analysis. Br. J. Ophthalmol., 2020, 104(8), 1077-1084.
[http://dx.doi.org/10.1136/bjophthalmol-2019-314422] [PMID: 31712255]
[3]
Colijn, J.M.; Buitendijk, G.H.S.; Prokofyeva, E.; Alves, D.; Cachulo, M.L.; Khawaja, A.P.; Cougnard-Gregoire, A.; Merle, B.M.J.; Korb, C.; Erke, M.G.; Bron, A.; Anastasopoulos, E.; Meester-Smoor, M.A.; Segato, T.; Piermarocchi, S.; de Jong, P.T.V.M.; Vingerling, J.R.; Topouzis, F.; Creuzot-Garcher, C.; Bertelsen, G.; Pfeiffer, N.; Fletcher, A.E.; Foster, P.J.; Silva, R.; Korobelnik, J.F.; Delcourt, C.; Klaver, C.C.W.; Ajana, S.; Arango-Gonzalez, B.; Arndt, V.; Bhatia, V.; Bhattacharya, S.S.; Biarnés, M.; Borrell, A.; Bühren, S.; Calado, S.M.; Colijn, J.M.; Cougnard-Grégoire, A.; Dammeier, S.; de Jong, E.K.; De la Cerda, B.; Delcourt, C.; den Hollander, A.I.; Diaz-Corrales, F.J.; Diether, S.; Emri, E.; Endermann, T.; Ferraro, L.L.; Garcia, M.; Heesterbeek, T.J.; Honisch, S.; Hoyng, C.B.; Kersten, E.; Kilger, E.; Klaver, C.C.W.; Langen, H.; Lengyel, I.; Luthert, P.; Maugeais, C.; Meester-Smoor, M.; Merle, B.M.J.; Monés, J.; Nogoceke, E.; Peto, T.; Pool, F.M.; Rodríguez, E.; Ueffing, M.; Ulrich Bartz-Schmidt, K.U.; van Leeuwen, E.M.; Verzijden, T.; Zumbansen, M.; Acar, N.; Anastosopoulos, E.; Azuara-Blanco, A.; Bergen, A.; Bertelsen, G.; Binquet, C.; Bird, A.; Brétillon, L.; Bron, A.; Buitendijk, G.; Cachulo, M.L.; Chakravarthy, U.; Chan, M.; Chang, P.; Colijn, J.; Cougnard-Grégoire, A.; Creuzot-Garcher, C.; Cumberland, P.; Cunha-Vaz, J.; Daien, V.; Deak, G.; Delcourt, C.; Delyfer, M-N.; den Hollander, A.; Dietzel, M.; Erke, M.G.; Fauser, S.; Finger, R.; Fletcher, A.; Foster, P.; Founti, P.; Göbel, A.; Gorgels, T.; Grauslund, J.; Grus, F.; Hammond, C.; Helmer, C.; Hense, H-W.; Hermann, M.; Hoehn, R.; Hogg, R.; Holz, F.; Hoyng, C.; Jansonius, N.; Janssen, S.; Khawaja, A.; Klaver, C.; Korobelnik, J-F.; Lamparter, J.; Le Goff, M.; Leal, S.; Lechanteur, Y.; Lehtimäki, T.; Lotery, A.; Leung, I.; Mauschitz, M.; Merle, B.; Meyer zu Westrup, V.; Midena, E.; Miotto, S.; Mirshahi, A.; Mohan-Saïd, S.; Mueller, M.; Muldrew, A.; Nunes, S.; Oexle, K.; Peto, T.; Piermarocchi, S.; Prokofyeva, E.; Rahi, J.; Raitakari, O.; Ribeiro, L.; Rougier, M-B.; Sahel, J.; Salonikiou, A.; Sanchez, C.; Schmitz-Valckenberg, S.; Schweitzer, C.; Segato, T.; Shehata, J.; Silva, R.; Silvestri, G.; Simader, C.; Souied, E.; Springelkamp, H.; Tapp, R.; Topouzis, F.; Verhoeven, V.; Von Hanno, T.; Vujosevic, S.; Williams, K.; Wolfram, C.; Yip, J.; Zerbib, J.; Zwiener, I. EYE-RISK consortium; European Eye Epidemiology (E3) consortium. Prevalence of age-related macular degeneration in Europe: The past and the future. Ophthalmology, 2017, 124(12), 1753-1763.
[http://dx.doi.org/10.1016/j.ophtha.2017.05.035] [PMID: 28712657]
[4]
Smith, W.; Assink, J.; Klein, R.; Mitchell, P.; Klaver, C.C.; Klein, B.E.; Hofman, A.; Jensen, S.; Wang, J.J.; de Jong, P.T. Risk factors for age-related macular degeneration: Pooled findings from three continents. Ophthalmology, 2001, 108(4), 697-704.
[http://dx.doi.org/10.1016/S0161-6420(00)00580-7] [PMID: 11297486]
[5]
Somasundaran, S.; Constable, I.J.; Mellough, C.B.; Carvalho, L.S. Retinal pigment epithelium and age-related macular degeneration: A review of major disease mechanisms. Clin. Exp. Ophthalmol., 2020, 48(8), 1043-1056.
[http://dx.doi.org/10.1111/ceo.13834] [PMID: 32710488]
[6]
Al-Zamil, W.M.; Yassin, S.A. Recent developments in age-related macular degeneration: A review. Clin. Interv. Aging, 2017, 12, 1313-1330.
[http://dx.doi.org/10.2147/CIA.S143508] [PMID: 28860733]
[7]
Winkler, B.S.; Boulton, M.E.; Gottsch, J.D.; Sternberg, P. Oxidative damage and age-related macular degeneration. Mol. Vis., 1999, 5, 32.
[PMID: 10562656]
[8]
Schmitz-Valckenberg, S.; Fleckenstein, M.; Scholl, H.P.; Holz, F.G. Fundus autofluorescence and progression of age-related macular degeneration. Surv. Ophthalmol., 2009, 54(1), 96-117.
[http://dx.doi.org/10.1016/j.survophthal.2008.10.004] [PMID: 19171212]
[9]
Johnson, L.V.; Leitner, W.P.; Staples, M.K.; Anderson, D.H. Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Exp. Eye Res., 2001, 73(6), 887-896.
[http://dx.doi.org/10.1006/exer.2001.1094] [PMID: 11846519]
[10]
Thurman, J.M.; Renner, B.; Kunchithapautham, K.; Ferreira, V.P.; Pangburn, M.K.; Ablonczy, Z.; Tomlinson, S.; Holers, V.M.; Rohrer, B. Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury. J. Biol. Chem., 2009, 284(25), 16939-16947.
[http://dx.doi.org/10.1074/jbc.M808166200] [PMID: 19386604]
[11]
Hahn, P.; Acquah, K.; Cousins, S.W.; Lee, P.P.; Sloan, F.A. Ten-year incidence of age-related macular degeneration according to diabetic retinopathy classification among medicare beneficiaries. Retina, 2013, 33(5), 911-919.
[http://dx.doi.org/10.1097/IAE.0b013e3182831248] [PMID: 23407352]
[12]
Zhang, Q.Y.; Tie, L.J.; Wu, S.S.; Lv, P.L.; Huang, H.W.; Wang, W.Q.; Wang, H.; Ma, L. Overweight, obesity, and risk of age-related macular degeneration. Invest. Ophthalmol. Vis. Sci., 2016, 57(3), 1276-1283.
[http://dx.doi.org/10.1167/iovs.15-18637] [PMID: 26990164]
[13]
Adams, M.K.; Simpson, J.A.; Aung, K.Z.; Makeyeva, G.A.; Giles, G.G.; English, D.R.; Hopper, J.; Guymer, R.H.; Baird, P.N.; Robman, L.D. Abdominal obesity and age-related macular degeneration. Am. J. Epidemiol., 2011, 173(11), 1246-1255.
[http://dx.doi.org/10.1093/aje/kwr005] [PMID: 21422060]
[14]
Stahl, A. The diagnosis and treatment of age-related macular degeneration. Dtsch. Arztebl. Int., 2020, 117(29-30), 513-520.
[http://dx.doi.org/10.3238/arztebl.2020.0513] [PMID: 33087239]
[15]
Rinninella, E.; Mele, M.C.; Merendino, N.; Cintoni, M.; Anselmi, G.; Caporossi, A.; Gasbarrini, A.; Minnella, A.M. The role of diet, micronutrients and the gut microbiota in age-related macular degeneration: New perspectives from the gut-retina axis. Nutrients, 2018, 10(11), E1677.
[http://dx.doi.org/10.3390/nu10111677] [PMID: 30400586]
[16]
Evans, JR; Lawrenson, JG A review of the evidence for dietary interventions in preventing or slowing the progression of age-related macular degeneration. Ophthalmic Physiol Opt, 2014, 34, 390-396.
[http://dx.doi.org/10.1111/opo.12142]
[17]
Cammalleri, M.; Dal Monte, M.; Locri, F.; Lardner, E.; Kvanta, A.; Rusciano, D.; André, H.; Bagnoli, P. Efficacy of a fatty acids dietary supplement in a polyethylene glycol-induced mouse model of retinal degeneration. Nutrients, 2017, 9(10), E1079.
[http://dx.doi.org/10.3390/nu9101079] [PMID: 28961167]
[18]
Yanai, R.; Mulki, L.; Hasegawa, E.; Takeuchi, K.; Sweigard, H.; Suzuki, J.; Gaissert, P.; Vavvas, D.G.; Sonoda, K.H.; Rothe, M.; Schunck, W.H.; Miller, J.W.; Connor, K.M. Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization. Proc. Natl. Acad. Sci. USA, 2014, 111(26), 9603-9608.
[http://dx.doi.org/10.1073/pnas.1401191111] [PMID: 24979774]
[19]
Yanai, R.; Chen, S.; Uchi, S.H.; Nanri, T.; Connor, K.M.; Kimura, K. Attenuation of choroidal neovascularization by dietary intake of ω-3 long-chain polyunsaturated fatty acids and lutein in mice. PLoS One, 2018, 13(4), e0196037.
[http://dx.doi.org/10.1371/journal.pone.0196037] [PMID: 29694386]
[20]
Gong, Y.; Fu, Z.; Liegl, R.; Chen, J.; Hellström, A.; Smith, L.E. ω-3 and ω-6 long-chain PUFAs and their enzymatic metabolites in neovascular eye diseases. Am. J. Clin. Nutr., 2017, 106(1), 16-26.
[http://dx.doi.org/10.3945/ajcn.117.153825] [PMID: 28515072]
[21]
Tuo, J.; Bojanowski, C.M.; Zhou, M.; Shen, D.; Ross, R.J.; Rosenberg, K.I.; Cameron, D.J.; Yin, C.; Kowalak, J.A.; Zhuang, Z.; Zhang, K.; Chan, C.C. Murine CCL2/CX3CR1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest. Ophthalmol. Vis. Sci., 2007, 48(8), 3827-3836.
[http://dx.doi.org/10.1167/iovs.07-0051] [PMID: 17652758]
[22]
Neuringer, M.; Francis, P.J.; Renner, L.; Weiss, A.; Jeffrey, BG. Atrophic macular degeneration in rhesus monkeys deficient in xanthophylls and n-3 fatty acids. Invest Ophth Vis Sci., 2010, 51(31), 2786.
[23]
Chapman, N.A.; Jacobs, R.J.; Braakhuis, A.J. Role of diet and food intake in age-related macular degeneration: A systematic review. Clin. Exp. Ophthalmol., 2019, 47(1), 106-127.
[http://dx.doi.org/10.1111/ceo.13343] [PMID: 29927057]
[24]
Wu, J.; Cho, E.; Giovannucci, E.L.; Rosner, B.A.; Sastry, S.M.; Willett, W.C.; Schaumberg, D.A. Dietary intakes of eicosapentaenoic acid and docosahexaenoic acid and risk of age-related macular degeneration. Ophthalmology, 2017, 124(5), 634-643.
[http://dx.doi.org/10.1016/j.ophtha.2016.12.033] [PMID: 28153441]
[25]
Joachim, N.; Mitchell, P.; Burlutsky, G.; Kifley, A.; Wang, J.J. The incidence and progression of age-related macular degeneration over 15 years: The blue mountains eye study. Ophthalmology, 2015, 122(12), 2482-2489.
[http://dx.doi.org/10.1016/j.ophtha.2015.08.002] [PMID: 26383995]
[26]
Christen, WG; Schaumberg, DA; Glynn, RJ; Buring, JE Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women. Arch. Ophthalmol., 2011, 129, 921-929.
[http://dx.doi.org/10.1001/archophthalmol.2011.34]
[27]
SanGiovanni, J.P.; Chew, E.Y.; Clemons, T.E.; Davis, M.D.; Ferris, F.L., III; Gensler, G.R.; Kurinij, N.; Lindblad, A.S.; Milton, R.C.; Seddon, J.M.; Sperduto, RD The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS Report No. 20. Arch. Ophthalmol., 2007, 125, 671-679.
[http://dx.doi.org/10.1001/archopht.125.5.671]
[28]
SanGiovanni, JP; Chew, EY; Agrón, E; Clemons, TE; Ferris, FL, 3rd; Gensler, G; Lindblad, AS; Milton, RC; Seddon, JM; Klein, R; Sperduto, RD. The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23. Arch. Ophthalmol., 2008, 126, 1274-1279.
[http://dx.doi.org/10.1001/archopht.126.9.1274]
[29]
SanGiovanni, JP; Agrón, E; Clemons, TE; Chew, EY. Omega-3 long-chain polyunsaturated fatty acid intake inversely associated with 12-year progression to advanced age-related macular degeneration. Arch. Ophthalmol., 2009, 127, 110-112.
[http://dx.doi.org/10.1001/archophthalmol.2008.518]
[30]
Seddon, JM; George, S.; Rosner, B. Cigarette smoking, fish consumption, omega-3 fatty acid intake, and associations with age-related macular degeneration: The US Twin Study of Age-Related Macular Degeneration. Arch. Ophthalmol., 2006, 124, 995-1001.
[http://dx.doi.org/10.1001/archopht.124.7.995]
[31]
Chong, EW; Robman, LD; Simpson, JA; Hodge, AM; Aung, KZ; Dolphin, TK; English, DR; Giles, GG.; Guymer, RH. Fat consumption and its association with age-related macular degeneration. Arch. Ophthalmol., 2009, 127, 674-680.
[http://dx.doi.org/10.1001/archophthalmol.2009.60]
[32]
Chua, B; Flood, V; Rochtchina, E; Wang, JJ; Smith, W; Mitchell, P Dietary fatty acids and the 5-year incidence of age-related maculopathy. Arch. Ophthalmol., 2006, 124, 981-986.
[http://dx.doi.org/10.1001/archopht.124.7.981]
[33]
Souied, E.H.; Delcourt, C.; Querques, G.; Bassols, A.; Merle, B.; Zourdani, A.; Smith, T.; Benlian, P. Nutritional AMD Treatment 2 Study Group. Oral docosahexaenoic acid in the prevention of exudative age-related macular degeneration: The Nutritional AMD Treatment 2 study. Ophthalmology, 2013, 120(8), 1619-1631.
[http://dx.doi.org/10.1016/j.ophtha.2013.01.005] [PMID: 23395546]
[34]
Augood, C.; Chakravarthy, U.; Young, I.; Vioque, J.; de Jong, P.T.; Bentham, G.; Rahu, M.; Seland, J.; Soubrane, G.; Tomazzoli, L.; Topouzis, F.; Vingerling, J.R.; Fletcher, A.E. Oily fish consumption, dietary docosahexaenoic acid and eicosapentaenoic acid intakes, and associations with neovascular age-related macular degeneration. Am. J. Clin. Nutr., 2008, 88(2), 398-406.
[http://dx.doi.org/10.1093/ajcn/88.2.398] [PMID: 18689376]
[35]
Merle, B.M.; Benlian, P.; Puche, N.; Bassols, A.; Delcourt, C.; Souied, E.H. Nutritional AMD Treatment 2 Study Group. Circulating omega-3 fatty acids and neovascular age-related macular degeneration. Invest. Ophthalmol. Vis. Sci., 2014, 55(3), 2010-2019.
[http://dx.doi.org/10.1167/iovs.14-13916] [PMID: 24557349]
[36]
Schleicher, M.; Weikel, K.; Garber, C.; Taylor, A. Diminishing risk for age-related macular degeneration with nutrition: A current view. Nutrients, 2013, 5(7), 2405-2456.
[http://dx.doi.org/10.3390/nu5072405] [PMID: 23820727]
[37]
Smith, W; Mitchell, P.; Leeder, SR. Dietary fat and fish intake and age-related maculopathy. Arch. Ophthalmol., 2000, 118, 401-404.
[http://dx.doi.org/10.1001/archopht.118.3.401]
[38]
Handelman, G.J.; Dratz, E.A.; Reay, C.C.; van Kuijk, J.G. Carotenoids in the human macula and whole retina. Invest. Ophthalmol. Vis. Sci., 1988, 29(6), 850-855.
[PMID: 3372162]
[39]
Carpentier, S.; Knaus, M.; Suh, M. Associations between lutein, zeaxanthin, and age-related macular degeneration: An overview. Crit. Rev. Food Sci. Nutr., 2009, 49(4), 313-326.
[http://dx.doi.org/10.1080/10408390802066979] [PMID: 19234943]
[40]
Tuzcu, M.; Orhan, C.; Muz, O.E.; Sahin, N.; Juturu, V.; Sahin, K. Lutein and zeaxanthin isomers modulates lipid metabolism and the inflammatory state of retina in obesity-induced high-fat diet rodent model. BMC Ophthalmol., 2017, 17(1), 129.
[http://dx.doi.org/10.1186/s12886-017-0524-1] [PMID: 28738845]
[41]
Scripsema, N.K.; Hu, D.N.; Rosen, R.B. Lutein, zeaxanthin, and meso-zeaxanthin in the clinical management of eye disease. J. Ophthalmol., 2015, 2015, 865179.
[http://dx.doi.org/10.1155/2015/865179] [PMID: 26819755]
[42]
Tsao, R. Chemistry and biochemistry of dietary polyphenols. Nutrients, 2010, 2(12), 1231-1246.
[http://dx.doi.org/10.3390/nu2121231] [PMID: 22254006]
[43]
Li, Z.; Zhou, M.; Xing, T. Research progress on lipid lowering mechanism of dietary polyphenols. Xiandai Shipin Keji, 2019, 35, 322-328.
[44]
Wang, T.; Heianza, Y.; Sun, D.; Huang, T.; Ma, W.; Rimm, E.B.; Manson, J.E.; Hu, F.B.; Willett, W.C.; Qi, L. Improving adherence to healthy dietary patterns, genetic risk, and long term weight gain: Gene-diet interaction analysis in two prospective cohort studies. BMJ, 2018, 360, j5644.
[http://dx.doi.org/10.1136/bmj.j5644] [PMID: 29321156]
[45]
Ma, L.; Lin, X.M. Effects of lutein and zeaxanthin on aspects of eye health. J. Sci. Food Agric., 2010, 90(1), 2-12.
[http://dx.doi.org/10.1002/jsfa.3785] [PMID: 20355006]
[46]
Zhao, Z.; Li-Jiang, W.U.; Sun, X.J. Grape skin polyphenols regulate LC3-II and protecting retinal pigment epithelium. J. Shanghai Jiaotong Univ., 2014.
[47]
Chang, C.H.; Chiu, H.F.; Han, Y.C.; Chen, I.H.; Shen, Y.C.; Venkatakrishnan, K.; Wang, C.K. Photoprotective effects of cranberry juice and its various fractions against blue light-induced impairment in human retinal pigment epithelial cells. Pharm. Biol., 2017, 55(1), 571-580.
[http://dx.doi.org/10.1080/13880209.2016.1263344] [PMID: 27937080]
[48]
Perdices, L.; Fuentes-Broto, L.; Segura, F.; Cuenca, N.; Orduna-Hospital, E.; Pinilla, I. Epigallocatechin gallate slows retinal degeneration, reduces oxidative damage, and modifies circadian rhythms in P23H rats. Antioxidants, 2020, 9(8), 718.
[http://dx.doi.org/10.3390/antiox9080718] [PMID: 32784376]
[49]
Lee, B.L.; Kang, J.H.; Kim, H.M.; Jeong, S.H.; Jang, D.S.; Jang, Y.P.; Choung, S.Y. Polyphenol-enriched Vaccinium uliginosum L. fractions reduce retinal damage induced by blue light in A2E-laden ARPE19 cell cultures and mice. Nutr. Res., 2016, 36(12), 1402-1414.
[http://dx.doi.org/10.1016/j.nutres.2016.11.008] [PMID: 27993192]
[50]
Courtaut, F.; Scagliarini, A.; Aires, V.; Cornebise, C.; Pais de Barros, J.P.; Olmiere, C.; Delmas, D. VEGF-R2/Caveolin-1 pathway of undifferentiated ARPE-19 retina cells: A potential target as anti-VEGF-A therapy in wet AMD by resvega, an omega-3/polyphenol combination. Int. J. Mol. Sci., 2021, 22(12), 6590.
[http://dx.doi.org/10.3390/ijms22126590] [PMID: 34205419]
[51]
Liu, S.; Fang, Y.; Yu, J.; Chang, X. Hawthorn polyphenols reduce high glucose-induced inflammation and apoptosis in ARPE-19 cells by regulating miR-34a/SIRT1 to reduce acetylation. J. Food Biochem., 2021, 45(2), e13623.
[http://dx.doi.org/10.1111/jfbc.13623] [PMID: 33491221]
[52]
Querques, G.; Benlian, P.; Chanu, B.; Portal, C.; Coscas, G.; Soubrane, G.; Souied, E.H. Nutritional AMD treatment phase I (NAT-1): Feasibility of oral DHA supplementation in age-related macular degeneration. Eur. J. Ophthalmol., 2009, 19(1), 100-106.
[http://dx.doi.org/10.1177/112067210901900115] [PMID: 19123156]
[53]
Johnson, J.A.; Grande, J.P.; Roche, P.C.; Campbell, R.J.; Kumar, R. Immuno-localization of the calcitriol receptor, calbindin-D28k and the plasma membrane calcium pump in the human eye. Curr. Eye Res., 1995, 14(2), 101-108.
[http://dx.doi.org/10.3109/02713689508999921] [PMID: 7539352]
[54]
Wang, H.; Hartnett, M.E. Regulation of signaling events involved in the pathophysiology of neovascular AMD. Mol. Vis., 2016, 22, 189-202.
[PMID: 27013848]
[55]
Parmeggiani, F.; Romano, M.R.; Costagliola, C.; Semeraro, F.; Incorvaia, C.; D’Angelo, S.; Perri, P.; De Palma, P.; De Nadai, K.; Sebastiani, A. Mechanism of inflammation in age-related macular degeneration. Mediators Inflamm., 2012, 2012, 546786.
[http://dx.doi.org/10.1155/2012/546786] [PMID: 23209345]
[56]
Uwitonze, A.M.; Razzaque, M.S. Role of magnesium in vitamin D activation and function. J. Am. Osteopath. Assoc., 2018, 118(3), 181-189.
[http://dx.doi.org/10.7556/jaoa.2018.037] [PMID: 29480918]
[57]
Akimbekov, N.S.; Digel, I.; Sherelkhan, D.K.; Lutfor, A.B.; Razzaque, M.S. Vitamin D and the host-gut microbiome: A brief overview. Acta Histochem. Cytochem., 2020, 53(3), 33-42.
[http://dx.doi.org/10.1267/ahc.20011] [PMID: 32624628]
[58]
Assa, A.; Vong, L.; Pinnell, L.J.; Rautava, J.; Avitzur, N.; Johnson-Henry, K.C.; Sherman, P.M. Vitamin D deficiency predisposes to adherent-invasive Escherichia coli-induced barrier dysfunction and experimental colonic injury. Inflamm. Bowel Dis., 2015, 21(2), 297-306.
[http://dx.doi.org/10.1097/MIB.0000000000000282] [PMID: 25590952]
[59]
Zhang, Y.G.; Lu, R.; Xia, Y.; Zhou, D.; Petrof, E.; Claud, E.C.; Sun, J. Lack of vitamin D receptor leads to hyperfunction of claudin-2 in intestinal inflammatory responses. Inflamm. Bowel Dis., 2019, 25(1), 97-110.
[http://dx.doi.org/10.1093/ibd/izy292] [PMID: 30289450]
[60]
Kamen, D.L.; Tangpricha, V. Vitamin D and molecular actions on the immune system: Modulation of innate and autoimmunity. J. Mol. Med. (Berl.), 2010, 88(5), 441-450.
[http://dx.doi.org/10.1007/s00109-010-0590-9] [PMID: 20119827]
[61]
Wang, T.T.; Dabbas, B.; Laperriere, D.; Bitton, A.J.; Soualhine, H.; Tavera-Mendoza, L.E.; Dionne, S.; Servant, M.J.; Bitton, A.; Seidman, E.G.; Mader, S.; Behr, M.A.; White, J.H. Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease. J. Biol. Chem., 2010, 285(4), 2227-2231.
[http://dx.doi.org/10.1074/jbc.C109.071225] [PMID: 19948723]
[62]
Evans, J.R.; Lawrenson, J.G. Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration. Cochrane Database Syst. Rev., 2017, 7(7), CD000253.
[http://dx.doi.org/10.1002/14651858.CD000253.pub4] [PMID: 28756617]
[63]
Kaushik, S.; Wang, J.J.; Flood, V.; Tan, J.S.; Barclay, A.W.; Wong, T.Y.; Brand-Miller, J.; Mitchell, P. Dietary glycemic index and the risk of age-related macular degeneration. Am. J. Clin. Nutr., 2008, 88(4), 1104-1110.
[http://dx.doi.org/10.1093/ajcn/88.4.1104] [PMID: 18842800]
[64]
Chiu, C.J.; Milton, R.C.; Klein, R.; Gensler, G.; Taylor, A. Dietary carbohydrate and the progression of age-related macular degeneration: A prospective study from the Age-Related Eye Disease Study. Am. J. Clin. Nutr., 2007, 86(4), 1210-1218.
[http://dx.doi.org/10.1093/ajcn/86.4.1210] [PMID: 17921404]
[65]
Sundelin, S.P.; Nilsson, S.E.; Brunk, U.T. Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content. Free Radic. Biol. Med., 2001, 30(1), 74-81.
[http://dx.doi.org/10.1016/S0891-5849(00)00444-5] [PMID: 11134897]
[66]
Piermarocchi, S.; Saviano, S.; Parisi, V.; Tedeschi, M.; Panozzo, G.; Scarpa, G.; Boschi, G.; Lo Giudice, G. Carmis Study Group. Carotenoids in age-related maculopathy italian study (CARMIS): Two-year results of a randomized study. Eur. J. Ophthalmol., 2012, 22(2), 216-225.
[http://dx.doi.org/10.5301/ejo.5000069] [PMID: 22009916]
[67]
Chew, E.Y.; Clemons, T.; SanGiovanni, J.P.; Danis, R.; Domalpally, A.; McBee, W.; Sperduto, R.; Ferris, F.L. AREDS2 Research Group. The age-related eye disease study 2 (AREDS2): Study design and baseline characteristics (AREDS2 report number 1). Ophthalmology, 2012, 119(11), 2282-2289.
[http://dx.doi.org/10.1016/j.ophtha.2012.05.027] [PMID: 22840421]
[68]
Aoki, A.; Inoue, M.; Nguyen, E.; Obata, R.; Kadonosono, K.; Shinkai, S.; Hashimoto, H.; Sasaki, S.; Yanagi, Y. Dietary n-3 fatty acid, α-tocopherol, zinc, vitamin D, vitamin C, and β-carotene are associated with age-related macular degeneration in Japan. Sci. Rep., 2016, 6(1), 20723.
[http://dx.doi.org/10.1038/srep20723] [PMID: 26846575]
[69]
Richer, S.; Stiles, W.; Statkute, L.; Pulido, J.; Frankowski, J.; Rudy, D.; Pei, K.; Tsipursky, M.; Nyland, J. Double-masked, placebo-controlled, randomized trial of lutein and antioxidant supplementation in the intervention of atrophic age-related macular degeneration: The Veterans LAST study (Lutein Antioxidant Supplementation Trial). Optometry, 2004, 75(4), 216-230.
[http://dx.doi.org/10.1016/S1529-1839(04)70049-4] [PMID: 15117055]
[70]
Delcourt, C.; Carrière, I.; Delage, M.; Barberger-Gateau, P.; Schalch, W. POLA Study Group. Plasma lutein and zeaxanthin and other carotenoids as modifiable risk factors for age-related maculopathy and cataract: The POLA Study. Invest. Ophthalmol. Vis. Sci., 2006, 47(6), 2329-2335.
[http://dx.doi.org/10.1167/iovs.05-1235] [PMID: 16723441]
[71]
Tan, J.S.; Wang, J.J.; Flood, V.; Rochtchina, E.; Smith, W.; Mitchell, P. Dietary antioxidants and the long-term incidence of age-related macular degeneration: The Blue Mountains Eye Study. Ophthalmology, 2008, 115(2), 334-341.
[http://dx.doi.org/10.1016/j.ophtha.2007.03.083] [PMID: 17664009]
[72]
Newsome, D.A. A randomized, prospective, placebo-controlled clinical trial of a novel zinc-monocysteine compound in age-related macular degeneration. Curr. Eye Res., 2008, 33(7), 591-598.
[http://dx.doi.org/10.1080/02713680802178437] [PMID: 18600492]
[73]
Snellen, E.L.; Verbeek, A.L.; Van Den Hoogen, G.W.; Cruysberg, J.R.; Hoyng, C.B. Neovascular age-related macular degeneration and its relationship to antioxidant intake. Acta Ophthalmol. Scand., 2002, 80(4), 368-371.
[http://dx.doi.org/10.1034/j.1600-0420.2002.800404.x] [PMID: 12190777]
[74]
Braakhuis, A.; Raman, R.; Vaghefi, E. The association between dietary intake of antioxidants and ocular disease. Diseases, 2017, 5(1), E3.
[http://dx.doi.org/10.3390/diseases5010003] [PMID: 28933356]
[75]
Taylor, H.R.; Tikellis, G.; Robman, L.D.; McCarty, C.A.; McNeil, J.J. Vitamin E supplementation and macular degeneration: Randomised controlled trial. BMJ, 2002, 325(7354), 11.
[http://dx.doi.org/10.1136/bmj.325.7354.11] [PMID: 12098721]
[76]
de Koning-Backus, A.P.M.; Buitendijk, G.H.S.; Kiefte-de Jong, J.C.; Colijn, J.M.; Hofman, A.; Vingerling, J.R.; Haverkort, E.B.; Franco, O.H.; Klaver, C.C.W. Intake of vegetables, fruit, and fish is beneficial for age-related macular degeneration. Am. J. Ophthalmol., 2019, 198, 70-79.
[http://dx.doi.org/10.1016/j.ajo.2018.09.036] [PMID: 30312575]
[77]
Mares-Perlman, JA; Brady, WE; Klein, R; Klein, BE; Bowen, P; Stacewicz-Sapuntzakis, M.; Palta, M. Serum antioxidants and age-related macular degeneration in a population-based case-control study. Arch. Ophthalmol., 1995, 113, 1518-1523.
[http://dx.doi.org/10.1001/archopht.1995.01100120048007]
[78]
VandenLangenberg, G.M.; Mares-Perlman, J.A.; Klein, R.; Klein, B.E.; Brady, W.E.; Palta, M. Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study. Am. J. Epidemiol., 1998, 148(2), 204-214.
[http://dx.doi.org/10.1093/oxfordjournals.aje.a009625] [PMID: 9676703]
[79]
Cougnard-Grégoire, A.; Merle, B.M.; Korobelnik, J.F.; Rougier, M.B.; Delyfer, M.N.; Le Goff, M.; Samieri, C.; Dartigues, J.F.; Delcourt, C. Olive oil consumption and age-related macular degeneration: The alienor study. PLoS One, 2016, 11(7), e0160240.
[http://dx.doi.org/10.1371/journal.pone.0160240] [PMID: 27467382]
[80]
Amirul Islam, F.M.; Chong, E.W.; Hodge, A.M.; Guymer, R.H.; Aung, K.Z.; Makeyeva, G.A.; Baird, P.N.; Hopper, J.L.; English, D.R.; Giles, G.G.; Robman, L.D. Dietary patterns and their associations with age-related macular degeneration: The Melbourne collaborative cohort study. Ophthalmology, 2014, 121(7), 1428-1434.e2.
[http://dx.doi.org/10.1016/j.ophtha.2014.01.002] [PMID: 24560564]
[81]
Chiu, C.J.; Chang, M.L.; Zhang, F.F.; Li, T.; Gensler, G.; Schleicher, M.; Taylor, A. The relationship of major American dietary patterns to age-related macular degeneration. Am. J. Ophthalmol., 2014, 158(1), 118-127.e1.
[http://dx.doi.org/10.1016/j.ajo.2014.04.016] [PMID: 24792100]
[82]
Merle, B.M.; Silver, R.E.; Rosner, B.; Seddon, J.M. Adherence to a Mediterranean diet, genetic susceptibility, and progression to advanced macular degeneration: A prospective cohort study. Am. J. Clin. Nutr., 2015, 102(5), 1196-1206.
[http://dx.doi.org/10.3945/ajcn.115.111047] [PMID: 26490493]
[83]
Hogg, R.E.; Woodside, J.V.; McGrath, A.; Young, I.S.; Vioque, J.L.; Chakravarthy, U.; de Jong, P.T.; Rahu, M.; Seland, J.; Soubrane, G.; Tomazzoli, L.; Topouzis, F.; Fletcher, A.E. Mediterranean diet score and its association with age-related macular degeneration: The European eye study. Ophthalmology, 2017, 124(1), 82-89.
[http://dx.doi.org/10.1016/j.ophtha.2016.09.019] [PMID: 27825655]
[84]
Jacobs, L. Probiotics, prebiotics, and synbiotics: What are they and how do they affect obesity? J. Pediatr. Surg. Nurs., 2017, 6(3), 53-55.
[http://dx.doi.org/10.1097/JPS.0000000000000140]
[85]
Andriessen, E.M.; Wilson, A.M.; Mawambo, G.; Dejda, A.; Miloudi, K.; Sennlaub, F.; Sapieha, P. Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization. EMBO Mol. Med., 2016, 8(12), 1366-1379.
[http://dx.doi.org/10.15252/emmm.201606531] [PMID: 27861126]
[86]
Rowan, S.; Jiang, S.; Korem, T.; Szymanski, J.; Chang, M.L.; Szelog, J.; Cassalman, C.; Dasuri, K.; McGuire, C.; Nagai, R.; Du, X.L.; Brownlee, M.; Rabbani, N.; Thornalley, P.J.; Baleja, J.D.; Deik, A.A.; Pierce, K.A.; Scott, J.M.; Clish, C.B.; Smith, D.E.; Weinberger, A.; Avnit-Sagi, T.; Lotan-Pompan, M.; Segal, E.; Taylor, A. Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration. Proc. Natl. Acad. Sci. USA, 2017, 114(22), E4472-E4481.
[http://dx.doi.org/10.1073/pnas.1702302114] [PMID: 28507131]
[87]
Zinkernagel, M.S.; Zysset-Burri, D.C.; Keller, I.; Berger, L.E.; Leichtle, A.B.; Largiadèr, C.R.; Fiedler, G.M.; Wolf, S. Association of the intestinal microbiome with the development of neovascular age-related macular degeneration. Sci. Rep., 2017, 7(1), 40826.
[http://dx.doi.org/10.1038/srep40826] [PMID: 28094305]
[88]
Rowan, S.; Taylor, A. Gut microbiota modify risk for dietary glycemia-induced age-related macular degeneration. Gut Microbes, 2018, 9(5), 452-457.
[http://dx.doi.org/10.1080/19490976.2018.1435247] [PMID: 29431583]
[89]
Zysset-Burri, D.C.; Keller, I.; Berger, L.E.; Largiadèr, C.R.; Wittwer, M.; Wolf, S.; Zinkernagel, M.S. Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration. NPJ Genom. Med., 2020, 5(1), 34.
[http://dx.doi.org/10.1038/s41525-020-00141-0] [PMID: 32922859]

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