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Reviews on Recent Clinical Trials


ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Review Article

Patient-reported Outcome Measures in Perianal Fistulizing Crohn’s Disease

Author(s): Natália Sousa Freitas Queiroz*, Karoline Soares Garcia, Eron Fabio Miranda and Paulo Gustavo Kotze

Volume 17, Issue 3, 2022

Published on: 02 August, 2022

Page: [143 - 155] Pages: 13

DOI: 10.2174/1574887117666220425125424

Price: $65


Perianal fistulizing Crohn’s disease (PFCD) is a disabling complication of Crohn’s disease (CD) that can significantly impact the patients’ quality of life (QoL) and often requires multidisciplinary care. Clinical trials assessing the efficacy of medical and surgical interventions for fistulas usually evaluate outcomes such as the closure of fistula tracts or radiologic healing. However, these traditional outcome assessments fail to capture the impact of the disease from patients’ perspectives. In this context, regulatory authorities have increasingly encouraged the inclusion of validated patient-reported outcomes (PRO) that assess disease activity and reveal how a patient functions and feels. This recent trend toward patient-centered care aims to ensure that improvements in efficacy outcomes are accompanied by meaningful benefits to patients. The aim of this review is to discuss currently available PRO measures (PROMS) for the assessment of PFCD to provide physicians with appropriate tools aiming to optimize patient care and disseminate the use of these instruments in clinical practice.

Keywords: Crohn’s disease, fistula, patient-reported outcome measures, quality of life, magnetic resonance imaging, rectal fistula.

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