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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Review Article

A Review on Experimental Models to Test Medicinal Plants on Postprandial Blood Glucose in Diabetes

Author(s): Sanae Abid and Mohamed Bnouham*

Volume 19, Issue 9, 2023

Published on: 03 November, 2022

Article ID: e080422203278 Pages: 8

DOI: 10.2174/1573399818666220408100830

Price: $65

Abstract

Due to the gravity of postprandial hyperglycemia in the development of microvascular and macrovascular diseases in diabetics, many medicinal plants are tested to determine their effectiveness in glycemic control and the mechanisms of action of the products. Consequently, various diabetic models have been developed and enhanced over the years.

The objective of this review is to describe some of the experimental models to study the effect of medicinal plants used to control postprandial hyperglycemia.

Data was collected from PubMed, ScienceDirect, Scopus, and Google scholar (1953-2021). Fiftyseven (57) studies were included in this review article.

Ten models were identified and described. For each model, we described the targets involved and their roles in postprandial blood glucose control. The experimental design and procedures described the targets such as an α-glucosidase enzyme, SGLT1, GLUT2, DPP-IV, Na+/K+ ATPase pump, or intestinal motility in the models, experiment design and procedures were described.

This review will facilitate the selection of the most appropriate model for studying agents used to investigate postprandial blood glucose.

Keywords: Diabetes, postprandial blood glucose models, medicinal plants, hyperglycemia, macrovascular diseases, intestinal motility.

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