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ISSN (Online): 1872-3136

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Review Article

A Critical Review on Recent Heterocyclics Identified for Anti-Leishmanial Therapy

Author(s): Swati Rathore, Adarsh Sahu*, Ram Kishore Agrawal and Asmita Gajbhiye Patil*

Volume 16, Issue 2, 2022

Published on: 21 July, 2022

Page: [81 - 105] Pages: 25

DOI: 10.2174/2212796816666220328130800

Price: $65

Abstract

Background: Leishmaniasis is a multifaceted disease that is prevalent worldwide. It is an epidemic, tropical/subtropical disease caused by macrophage infection by compulsive leishmania genus intracellular parasites affecting millions of people across the globe.

Methods: The demand for effective and safe molecules in the field of leishmaniasis is still an active research area. The lack of widely effective anti-leishmanial drugs, therefore, means a critical need for the production of modern, effective, affordable, and safe drugs for leishmaniasis care. In the recent past, many new pharmacophores have been synthesized and evaluated for their antileishmanial activity.

Conclusion: Many important heterocycles have proved to be effective against various leishmanial strains in terms of both safety and efficacy. In this article, we have attempted to review the different pharmacophores discovered in the past few years with the potential anti-leishmanial property.

Keywords: Anti-leishmanial activity, targets, pharmacophore, heterocyclic, TRND, chemotherapy.

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