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Current Traditional Medicine

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ISSN (Print): 2215-0838
ISSN (Online): 2215-0846

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Review Article

Role of Caffeine in Inducing Anxiety by Reducing Brain Serotonin Synthesis Blocking Adenosine Receptors (A1, A2A, A2B, and A3)

Author(s): Pooja Verma, Rohit Dutt and Siraj Anwar*

Volume 8, Issue 4, 2022

Published on: 20 May, 2022

Article ID: e210322202482 Pages: 9

DOI: 10.2174/2215083808666220321145436

Price: $65

Abstract

Caffeine is well-known for its stimulant characteristics and is included in a wide variety of foods, drinks, and pharmaceutical formulations worldwide. However, the methods by which caffeine exerts its effects on the brain were unknown until the past decade, when the development of strong research tools enabled scientists to explore the drug's neuropharmacological and biochemical characteristics. Serotonin, especially in sensitive people, also tends to decrease anxiety. Most of their biological effects are caused by antagonising all kinds of adenosine receptors (ARs): A1, A2A, A2B, and A3. Serotonin is a key Central Nervous System (CNS) neurotransmitter. The deregulation of the transmission of serotonin in the CNS is known to be associated with many human mental illnesses, including impulsive aggressiveness, depression, and anxiety disorders.

Keywords: Adenosine receptors, anxiety, caffeine, serotonin, psychotropic drugs, central nervous system (CNS).

Graphical Abstract

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