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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Mini-Review Article

Summary of Probiotic Potential of the Kefir for the Prevention and Alleviation of Functional GI Diseases

Author(s): Sheikh Saba Naz and Taqdees Malik*

Volume 18, Issue 6, 2022

Published on: 14 April, 2022

Page: [518 - 524] Pages: 7

DOI: 10.2174/1573401318666220321140726

Price: $65

Abstract

Background: Functional Gastrointestinal (GI) disease is a term that refers to a range of disease conditions involving chronic diarrhea, irritable bowel syndrome, constipation, inflammatory bowel disease (IBD), and lactose intolerance. Statistical reports have documented >40% of the world's population is being afflicted by functional GI disorders. Consequences of frequent intake of antibiotics include mortality of gut microflora, antibiotic-associated diarrhea, the establishment of antibiotic resistance, and inference with healthy bodily functions. To overcome the harms of antibiotics, studies are being conducted to determine the potential of probiotics as alternatives to antibiotics.

Aims: The purpose of constructing this literature review is to outline the potential attributes of Kefir and to assess the solitary efficiency of this beverage in the amelioration of GI disease conditions.

Methods: Extraction of data entailed digging of literature hubs including PubMed, PubMed Central, Research Gate, Science Direct, and Google Scholar, employing a different combination of keywords to retrieve substantial details. Selection criteria of the articles involved the published reports of preceding 10 years (2012-2021) that exhibited relevancy with the topic.

Conclusion: Kefir grains having different origins provide a distinct array of antimicrobial spectrums and are found to be effective against different pathogens. IBDs, diarrheal sicknesses, and constipation can be alleviated by the consumption of this beverage. Moreover, the probioticantibiotic combination is also essential for the mitigation of several diseases. The synergistic impact of several microbial strains is vital for the treatment of celiac disease. Lactose maldigestion can be relieved by the consumption of kefir having β-galactosidase enzyme activity.

Keywords: Kefir, probiotics, antimicrobial activity, gastrointestinal diseases, foodborne pathogens, diarrhea.

Graphical Abstract
[1]
Sperber AD, Bangdiwala SI, Drossman DA, et al. Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome Foundation Global Study. Gastroenterology 2021; 160(1): 99-114.e3.
[http://dx.doi.org/10.1053/j.gastro.2020.04.014] [PMID: 32294476]
[2]
Disorders GI. GI Disorders: Types, Symptoms & Treatment | imaware ™. Imaware. health. 2021. Available from: https://www.imaware.health/blog/most-common-GI-conditions (Accessed May 22, 2021).
[3]
Global Diarrhea Burden | Global Water, Sanitation and Hygiene | Healthy Water | CDC. Cdc.gov. 2021. Available from: https://www.cdc.gov/healthywater/global/diarrhea-burden.html#:~:text= Diarrhea%20kills%202%2C195%20children%20every,under%20t he%20age%20of%205 (Accessed May 22, 2021).
[4]
Oka P, Parr H, Barberio B, Black CJ, Savarino EV, Ford AC. Global prevalence of irritable bowel syndrome according to Rome III or IV criteria: A systematic review and meta-analysis. Lancet Gastroenterol Hepatol 2020; 5(10): 908-17.
[http://dx.doi.org/10.1016/S2468-1253(20)30217-X] [PMID: 32702295]
[5]
Forootan M, Bagheri N, Darvishi M. Chronic constipation: A review of literature. Medicine (Baltimore) 2018; 97(20): e10631.
[http://dx.doi.org/10.1097/MD.0000000000010631] [PMID: 29768326]
[6]
Jairath V, Feagan BG. Global burden of inflammatory bowel disease. Lancet Gastroenterol Hepatol 2020; 5(1): 2-3.
[http://dx.doi.org/10.1016/S2468-1253(19)30358-9] [PMID: 31648974]
[7]
Information H, Diseases D, Intolerance L, Facts D, Intolerance D, Health N. Definition & facts for lactose intolerance | NIDDK. National institute of diabetes and digestive and kidney. 2021. Available from: https://www.niddk.nih.gov/health-information/ digestive- diseases/lactose-intolerance/definitionfacts#:~:text=Experts%20 estimate%20that% 20about%2068,world's%20population%20has% 20lactose%20malabsorption.&text=Lactose%20malabsorption%20 is%20more%20common,most%20people%20have%20lactose%20 malabsorption (Accessed May 22, 2021).
[8]
Cunha BA. Antibiotic side effects. Med Clin North Am 2001; 85(1): 149-85.
[http://dx.doi.org/10.1016/S0025-7125(05)70309-6] [PMID: 11190350]
[9]
Lokesh D, Rajagopal K, Ho Shin J. Multidrug-resistant probiotics as an alternative to antibiotic probiotic therapy. J Infect (Grand Rapids) 2019; 2(4): 46-9.
[http://dx.doi.org/10.29245/2689-9981/2019/4.1147]
[10]
Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of action. Ann Nutr Metab 2012; 61(2): 160-74.
[http://dx.doi.org/10.1159/000342079] [PMID: 23037511]
[11]
Morais MB, Jacob CM. The role of probiotics and prebiotics in pediatric practice. J Pediatr (Rio J) 2006; 82(5)(Suppl.): S189-97.
[http://dx.doi.org/10.2223/JPED.1559] [PMID: 17136295]
[12]
de Oliveira Leite AM, Miguel MA, Peixoto RS, Rosado AS, Silva JT, Paschoalin VM. Microbiological, technological and therapeutic properties of kefir: A natural probiotic beverage. Braz J Microbiol 2013; 44(2): 341-9.
[13]
Peluzio MDCG, Dias MME, Martinez JA, Milagro FI. Kefir and intestinal microbiota modulation: Implications in human health. Front Nutr 2021; 8: 638740.
[http://dx.doi.org/10.3389/fnut.2021.638740]
[14]
Kim DH, Jeong D, Kim H, et al. Antimicrobial activity of kefir against various food pathogens and spoilage bacteria. Han-gug Chugsan Sigpum Hag-hoeji 2016; 36(6): 787-90.
[http://dx.doi.org/10.5851/kosfa.2016.36.6.787] [PMID: 28115890]
[15]
Santos J, Araújo T, Ferreira C, Goulart S. Evaluation of antagonistic activity of milk fermented with Kefir Grains of different origins. Braz Arch Biol Technol 2013; 56(5): 823-7.
[http://dx.doi.org/10.1590/S1516-89132013000500014]
[16]
Ulusoy B, Çolak H, Hampikyan H, Erkan M. An in vitro study on the antibacterial effect of kefir against some food-borne pathogens. J Turkish Microbiol Soc 2007; 37: 103-7.
[17]
Margarida M. Assessing the inhibitory activity of kefir produced with a lyophilized starter towards common foodborne pathogens. MSc Dissertation. 2017.
[18]
Kivanc M, Yapici E. Survival of Escherichia coli O157:H7 and Staphylococcus aureus during the fermentation and storage of kefir. Food Sci Technol (Campinas) 2019; 39(1): 225-30.
[http://dx.doi.org/10.1590/fst.39517]
[19]
Sirirat D, Jelena P. Bacterial inhibition and antioxidant activity of kefir produced from thai jasmine rice milk. Biotechnology (Faisalabad) 2010; 9(3): 332-7.
[http://dx.doi.org/10.3923/biotech.2010.332.337]
[20]
Chang-Liao WP, Lee A, Chiu YH, Chang HW, Liu JR. Isolation of a Leuconostoc mesenteroides strain with anti-porcine epidemic diarrhea virus activities from kefir grains. Front Microbiol 2020; 11: 1578.
[http://dx.doi.org/10.3389/fmicb.2020.01578] [PMID: 32760370]
[21]
Sninsky CA. New research in ulcerative colitis: Optimizing 5-ASA administration for efficacy and adherence. Gastroenterol Hepatol (N Y) 2010; 6(1): 4-16.
[PMID: 20567544]
[22]
Sevencan NO, Isler M, Kapucuoglu FN, et al. Dose-dependent effects of kefir on colitis induced by trinitrobenzene sulfonic acid in rats. Food Sci Nutr 2019; 7(9): 3110-8.
[http://dx.doi.org/10.1002/fsn3.1174]
[23]
Senol A, Isler M, Sutcu R, et al. Kefir treatment ameliorates dextran sulfate sodium-induced colitis in rats. World J Gastroenterol 2015; 21(46): 13020-9.
[http://dx.doi.org/10.3748/wjg.v21.i46.13020] [PMID: 26676086]
[24]
Seyedian SS, Nokhostin F, Malamir MD. A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease. J Med Life 2019; 12(2): 113-22.
[http://dx.doi.org/10.25122/jml-2018-0075] [PMID: 31406511]
[25]
Yılmaz İ, Dolar ME, Özpınar H. Effect of administering kefir on the changes in fecal microbiota and symptoms of inflammatory bowel disease: A randomized controlled trial. Turk J Gastroenterol 2019; 30(3): 242-53.
[http://dx.doi.org/10.5152/tjg.2018.18227] [PMID: 30662004]
[26]
Seo MK, Park EJ, Ko SY, Choi EW, Kim S. Therapeutic effects of kefir grain Lactobacillus-derived extracellular vesicles in mice with 2,4,6-trinitrobenzene sulfonic acid-induced inflammatory bowel disease. J Dairy Sci 2018; 101(10): 8662-71.
[http://dx.doi.org/10.3168/jds.2018-15014] [PMID: 30100498]
[27]
Curciarello R, Canziani KE, Salto I, et al. Probiotic lactobacilli isolated from kefir promote down-regulation of inflammatory lamina propria T cells from patients with active IBD. Front Pharmacol 2021; 12: 658026.
[http://dx.doi.org/10.3389/fphar.2021.658026]
[28]
Nemeth V, Pfleghaar N. Diarrhea. In: StatPearls. Treasure Island, FL: StatPearls Publishing 2021.
[29]
Bolla PA, Carasi P, Bolla ML, De Antoni GL, Serradell ML. Protective effect of a mixture of kefir-isolated lactic acid bacteria and yeasts in a hamster model of Clostridium difficile infection. Anaerobe 2013; 21: 28-33.
[http://dx.doi.org/10.1016/j.anaerobe.2013.03.010] [PMID: 23542116]
[30]
Zacconi C, Scolari G, Vescovo M, Sarra PG. Competitive exclusion of Campylobacter jejuni by kefir fermented milk. Ann Microbiol 2003; 53: 179-87.
[31]
Abatemarco Júnior M, Sandes SHC, Ricci MF, et al. Protective effect of Lactobacillus diolivorans 1Z, isolated from Brazilian kefir, against Salmonella enterica serovar typhimurium in experimental murine models. Front Microbiol 2018; 9: 2856.
[http://dx.doi.org/10.3389/fmicb.2018.02856]
[32]
Mühlen S, Dersch P. Treatment strategies for infections with shiga toxin-producing Escherichia coli. Front Cell Infect Microbiol 2020; 10: 169.
[http://dx.doi.org/10.3389/fcimb.2020.00169]
[33]
Chen YP, Lee TY, Hong WS, Hsieh HH, Chen MJ. Effects of Lactobacillus kefiranofaciens M1 isolated from kefir grains on enterohemorrhagic Escherichia coli infection using mouse and intestinal cell models. J Dairy Sci 2013; 96(12): 7467-77.
[http://dx.doi.org/10.3168/jds.2013-7015] [PMID: 24140320]
[34]
Bolla PA, Abraham AG, Pérez PF, de Los Angeles Serradell M. Kefir-isolated bacteria and yeasts inhibit Shigella flexneri invasion and modulate pro-inflammatory response on intestinal epithelial cells. Benef Microbes 2016; 7(1): 103-10.
[http://dx.doi.org/10.3920/BM2015.0061] [PMID: 26503738]
[35]
Turan İ, Dedeli Ö, Bor S, İlter T. Effects of a kefir supplement on symptoms, colonic transit, and bowel satisfaction score in patients with chronic constipation: A pilot study. Turk J Gastroenterol 2014; 25(6): 650-6.
[http://dx.doi.org/10.5152/tjg.2014.6990] [PMID: 25599776]
[36]
Ino M, Matsukawa M, Yamaoka Y, Hanada K, Fujii C. Prophylactic effects of kefir-fermented milk on constipation among mentally and physically handicapped persons. J Probiotics Health 2014; 3(1): 1-6.
[http://dx.doi.org/10.4172/2168-9776.1000126]
[37]
Maki R, Matsukawa M, Matsuduka A, et al. Therapeutic effect of lyophilized, Kefir-fermented milk on constipation among persons with mental and physical disabilities. Jpn J Nurs Sci 2018; 15(3): 218-25.
[http://dx.doi.org/10.1111/jjns.12189] [PMID: 29105976]
[38]
Sakai T, Kubota H, Gawad A, Gheyle L, Ramael S, Oishi K. Effect of fermented milk containing Lactobacillus casei strain Shirota on constipation-related symptoms and haemorrhoids in women during puerperium. Benef Microbes 2015; 6(3): 253-62.
[http://dx.doi.org/10.3920/BM2014.0076] [PMID: 25380801]
[39]
Wang J, Bai X, Peng C, et al. Fermented milk containing Lactobacillus casei Zhang and Bifidobacterium animalis ssp. lactis V9 alleviated constipation symptoms through regulation of intestinal microbiota, inflammation, and metabolic pathways. J Dairy Sci 2020; 103(12): 11025-38.
[http://dx.doi.org/10.3168/jds.2020-18639] [PMID: 33222846]
[40]
Parzanese I, Qehajaj D, Patrinicola F, et al. Celiac disease: From pathophysiology to treatment. World J Gastrointest Pathophysiol 2017; 8(2): 27-38.
[http://dx.doi.org/10.4291/wjgp.v8.i2.27] [PMID: 28573065]
[41]
Information H, Diseases D, Disease C, Causes S, Disease S, Health N. Symptoms & Causes of Celiac Disease | NIDDK. National Institute of Diabetes and Digestive and Kidney Diseases. 2021. Available from: https://www.niddk.nih.gov/health-information/ digestive- diseases/celiac-disease/symptoms-causes (Accessed May 11, 2021).
[42]
Lindfors K, Blomqvist T, Juuti-Uusitalo K, et al. Live probiotic Bifidobacterium lactis bacteria inhibit the toxic effects induced by wheat gliadin in epithelial cell culture. Clin Exp Immunol 2008; 152(3): 552-8.
[http://dx.doi.org/10.1111/j.1365-2249.2008.03635.x] [PMID: 18422736]
[43]
De Angelis M, Rizzello CG, Fasano A, et al. VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for Celiac Sprue. Biochim Biophys Acta 2006; 1762(1): 80-93.
[http://dx.doi.org/10.1016/j.bbadis.2005.09.008] [PMID: 16311022]
[44]
De Palma G, Cinova J, Stepankova R, Tuckova L, Sanz Y. Pivotal advance: Bifidobacteria and gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease. J Leukoc Biol 2010; 87(5): 765-78.
[http://dx.doi.org/10.1189/jlb.0709471] [PMID: 20007908]
[45]
Francavilla R, De Angelis M, Rizzello CG, Cavallo N, Dal Bello F, Gobbetti M. Selected probiotic lactobacilli have the capacity to hydrolyze gluten peptides during simulated GI digestion. Appl Environ Microbiol 2017; 83(14): e00376-e003717.
[http://dx.doi.org/10.1128/AEM.00376-17]
[46]
Suriasih K, Wayan R, Mahardika G. Microbiological and chemical properties of kefir made of bali cattle milk. FSQM 2012; 6: 12-23.
[47]
Shori A, Baba A. Viability of lactic acid bacteria and sensory evaluation in Cinnamomum verum and Allium sativum-bio-yogurts made from camel and cow milk. J Assoc Arab Univ Basic Appl Sci 2012; 11(1): 50-5.
[48]
Boynton W, Floch M. New strategies for the management of diverticular disease: Insights for the clinician. Therap Adv Gastroenterol 2013; 6(3): 205-13.
[http://dx.doi.org/10.1177/1756283X13478679] [PMID: 23634185]
[49]
Lamiki P, Tsuchiya J, Pathak S, et al. Probiotics in diverticular disease of the colon: An open label study. J Gastrointestin Liver Dis 2010; 19(1): 31-6.
[PMID: 20361072]
[50]
White JA. Probiotics and their use in diverticulitis. J Clin Gastroenterol 2006; 40(Suppl. 3): S160-2.
[http://dx.doi.org/10.1097/01.mcg.0000225504.67547.d9] [PMID: 16885701]
[51]
Tursi A, Brandimarte G, Elisei W, et al. Randomised clinical trial: Mesalazine and/or probiotics in maintaining remission of symptomatic uncomplicated diverticular disease-a double-blind, randomised, placebo-controlled study. Aliment Pharmacol Ther 2013; 38(7): 741-51.
[http://dx.doi.org/10.1111/apt.12463] [PMID: 23957734]
[52]
Kefir vs. yogurt: Nutrition, uses, where to buy, and more.year 2021. Available from: https://www.healthline.com/health/kefir-vs-yogurt#probiotics
[53]
Hertzler SR, Clancy SM. Kefir improves lactose digestion and tolerance in adults with lactose maldigestion. J Am Diet Assoc 2003; 103(5): 582-7.
[http://dx.doi.org/10.1053/jada.2003.50111] [PMID: 12728216]
[54]
Juers DH, Matthews BW, Huber RE. LacZ β-galactosidase: Structure and function of an enzyme of historical and molecular biological importance. Protein Sci 2012; 21(12): 1792-807.
[http://dx.doi.org/10.1002/pro.2165] [PMID: 23011886]

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