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Current Cancer Drug Targets

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma

Author(s): Ayana R. Kumar, Aswathy R. Devan, Bhagyalakshmi Nair, Reshma Ravindran Nair and Lekshmi R. Nath*

Volume 22, Issue 9, 2022

Published on: 08 June, 2022

Page: [725 - 740] Pages: 16

DOI: 10.2174/1568009622666220317090552

Price: $65

Abstract

Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC. HCC cells maintain an immune-suppressive environment with the help of immunesuppressive tumor-associated antigens, resulting in a metastatic spread of the disease. The development of intense immunotherapeutic strategies to target tumor-associated antigen is critical to overcoming the progression of HCC. MUC 1 remains the most recognized tumor-associated antigen since its discovery over 30 years ago. A few promising immunotherapies targeting MUC 1 are currently under clinical trials, including CAR-T and CAR-pNK-mediated therapies. This review highlights the biosynthesis, significance, and clinical implication of MUC 1 as an immune target in HCC.

Keywords: MUC 1, aberrant glycosylation, hepatocellular carcinoma, immune signaling, immunotherapy, highly glycosylated tumor-associated antigen (TAA).

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