Generic placeholder image

Current Chemical Biology

Editor-in-Chief

ISSN (Print): 2212-7968
ISSN (Online): 1872-3136

Review Article

Ethnopharmacology and Biological Activities of Aristolochia longa: A Review

Author(s): Mustapha Madani, Hasna Zinelabidine*, Abderrafia Hafid, Mostafa Khouili and Latifa Bouissane*

Volume 16, Issue 2, 2022

Published on: 13 May, 2022

Page: [106 - 122] Pages: 17

DOI: 10.2174/2212796816666220307104606

Price: $65

Abstract

Aristolochia longa is a plant belonging to the genus Aristolochia, family Aristolochiaceae, whose rhizomes represent the most important part used in the pharmaceutical field mainly due to its richness in bioactive molecules. Several investigations have shown numerous biological properties, including antibacterial, antifungal, anti-inflammatory, antioxidant, and anti-cancer activities. Besides, many chemical components such as alkaloids, glycosides, phenolic compounds, tannins, flavonoids, terpenoids, and saponins have been isolated, and their structures have been elucidated. However, Aristolochia longa is still not investigated. Therefore, more studies should be conducted to discover other biological activities of Aristolochia longa, as well as those of other species from the same genus, and identify compounds responsible for these activities.

Keywords: Aristolochia longa, bioactive secondary metabolites, biological activities, phamacodynamic, pharmacokinetic properties, phytochemicals.

Next »
Graphical Abstract
[1]
Matić S.; Stanić; S.; Mihailović; M.; Bogojević; D. Cotinus coggygria Scop.: An overview of its chemical constituents, pharmacological and toxicological potential. Saudi J. Biol. Sci., 2016, 23(4), 452-461.
[http://dx.doi.org/10.1016/j.sjbs.2015.05.012] [PMID: 27298577]
[2]
Ballabh, B.; Chaurasia, O.P.; Ahmed, Z.; Singh, S.B. Traditional medicinal plants of cold desert Ladakh-used against kidney and urinary disorders. J. Ethnopharmacol., 2008, 118(2), 331-339.
[http://dx.doi.org/10.1016/j.jep.2008.04.022] [PMID: 18550306]
[3]
Chitme, H.R.; Chandra, M.; Kaushik, S. Studies on anti-diarrhoeal activity of Calotropis gigantea R.Br. in experimental animals. J. Pharm. Pharm. Sci., 2004, 7(1), 70-75.
[PMID: 15144737]
[4]
Jamil, F.; Mostaf, E. An overview on ethnobotanico-pharmacological studies carried out in Morocco, from 1991 to 2015: Systematic review (part 1). J. Ethnopharmacol., 2020, 267(1), 113-200.
[5]
De Groot, H.; Wanke, S.; Neinhuis, C. Revision of the genus Aristolochia [Aristolochiaceae] in Africa, Madagascar and adjacent islands. Bot. J. Linn. Soc., 2006, 151(2), 219-238.
[http://dx.doi.org/10.1111/j.1095-8339.2006.00511.x]
[6]
Benarba, B.; Ambroise, G.; Aoues, A.; Meddah, B.; Vazquez, A. Aristolochia longa aqueous extract triggers the mitochondrial pathway of apoptosis in BL41 Burkitt’s lymphoma cells. Int. J. Green Pharm., 2012, 6(1), 45-49.
[http://dx.doi.org/10.4103/0973-8258.97128]
[7]
El Idrissi, A.E.Y.; Khouchlaa, A.; Bouyahya, A.; Bakri, Y.; Tijane, M. Phytochemical characterization, in vitro antioxidant, cytotoxic, and antibacterial effects of Aristolochia longa L. Biointerface Res. Appl. Chem., 2021, 11(1), 8129-8140.
[http://dx.doi.org/10.1111/j.1095-8339.2006.00511.x]
[8]
Dhouioui, M.; Boulila, A.; Jemli, M.; Schiets, F.; Casabianca, H.; Zina, M.S. Fatty acids composition and antibacterial activity of Aristolochia longa L. and Bryonia dioica Jacq. growing wild in Tunisia. J. Oleo Sci., 2016, 65(8), 655-661.
[http://dx.doi.org/10.5650/jos.ess16001] [PMID: 27430383]
[9]
Kelly, L.M.; González, F. Phylogenetic relationships in Aristolochiaceae. Syst. Bot., 2003, 28(2), 236-249.
[http://dx.doi.org/10.1043/0363-6445-28.2.236]
[10]
Wanke, S.; Jaramillo, M.A.; Borsch, T.; Samain, M-S.; Quandt, D.; Neinhuis, C. Evolution of Piperales--matK gene and trnK intron sequence data reveal lineage specific resolution contrast. Mol. Phylogenet. Evol., 2007, 42(2), 477-497.
[http://dx.doi.org/10.1016/j.ympev.2006.07.007] [PMID: 16978885]
[11]
Tian-Shung, W.; Chung-Ren, S.; Ping-Chung, K. Chemical constituents and pharmacology of Aristolochi species. Stud. Nat. Prod. Chem, 2005, 32(part L), 855-1018.
[http://dx.doi.org/10.1016/S1572-5995(05)80071-7]
[12]
Khan, M.E.; Amupitan, J.O.; Ndukwe, I.G. Bioactive evaluation and phytochemical screening of the roots of Aristolochia albida against some bacterial pathogens. Cont. J. Appl. Sci., 2011, 6(1), 7-14.
[13]
Zhai, H.; Nakatsukasa, M.; Mitsumoto, Y.; Fukuyama, Y. Neurotrophic effects of talaumidin, a neolignan from Aristolochia arcuata, in primary cultured rat cortical neurons. Planta Med., 2004, 70(7), 598-602.
[http://dx.doi.org/10.1055/s-2004-827179] [PMID: 15303251]
[14]
Bourhia, M.; Haj Said, A.A.; Chaanoun, A.; El Gueddari, F.; Naamane, A.; Benbacer, L.; Khlil, N. Phytochemical screening and toxicological study of Aristolochia baetica linn roots: Histopathological and biochemical evidence. J. Toxicol., 2019, 2019, 8203832.
[http://dx.doi.org/10.1155/2019/8203832] [PMID: 30853978]
[15]
Ozen, T.; Bora, N.; Yenigun, S.; Korkmaz, H. An investigation of chemical content, enzyme inhibitory propert, antioxidant and antibacterial activity of Aristolochia bodamae dingler (develiotu) (Aristolochiaceae) root extracts from Samsun, Turkey. Flavour Fragrance J., 2020, 35(3), 270-283.
[http://dx.doi.org/10.1002/ffj.3559]
[16]
Angalaparameswari, S.; Saleem, T.M.; Alagusundaram, M.; Ramkanth, S.; Thiruvengadarajan, V.S.; Gnanaprakash, K.; Chetty, C.M.; Pratheesh, G. Anti-microbial activity of aristolochic acid from root of Aristolochia bracteata Retz. Int. J Med. Hea. Biomed. Bioeng. Pharm. Eng., 2011, 5(9), 461-464.
[17]
Badami, S.; Jose, C.K.; Dongre, S.K.H.; Jagadish, P.C.; Suresh, B. In vitro antioxidant activity of various extracts of Aristolochia bracteolata leaves. Orient. Pharm. Exp. Med., 2005, 5(4), 316-321.
[http://dx.doi.org/10.3742/OPEM.2005.5.4.316]
[18]
Shirwaikar, A.; Somashekar, A.P.; Udupa, A.L.; Udupa, S.L.; Somashekar, S. Wound healing studies of Aristolochia bracteolata Lam. with supportive action of antioxidant enzymes. Phytomedicine, 2003, 10(6-7), 558-562.
[http://dx.doi.org/10.1078/094471103322331548] [PMID: 13678243]
[19]
Palanisamy, K.; Deepa, M.; Pushpa, R.; Kiruba, P.; Lenin, M. Screening and characterization of Aristolochia bracteolata plant extract against antibacterial activity of selected microbes. J. Pharmacogn. Phytochem., 2019, 8(3), 4573-4576.
[20]
Navarro-García, V.M.; Luna-Herrera, J.; Rojas-Bribiesca, M.G.; Álvarez-Fitz, P.; Ríos, M.Y. Antibacterial activity of Aristolochia brevipes against multidrug-resistant Mycobacterium tuberculosis. Molecules, 2011, 16(9), 7357-7364.
[http://dx.doi.org/10.3390/molecules16097357] [PMID: 21876482]
[21]
Nacsa-Farkas, E.; Pauliuc, I.; Krisch, J.; Vágvölgyi, C. Anticandidal effect of the extracts from Melilotus officinalis and Aristolochia clematitis. Rev. Agric. Rural Dev., 2013, 2(1), 473-477.
[22]
Wen, Y.J.; Su, T.; Tang, J.W.; Zhang, C.Y.; Wang, X.; Cai, S.Q.; Li, X.M. Cytotoxicity of phenanthrenes extracted from Aristolochia contorta in human proximal tubular epithelial cell line. Nephron, Exp. Nephrol., 2006, 103(3), e95-e102.
[http://dx.doi.org/10.1159/000092194] [PMID: 16554666]
[23]
Zhang, G.; Shimokawa, S.; Mochizuki, M.; Kumamoto, T.; Nakanishi, W.; Watanabe, T.; Ishikawa, T.; Matsumoto, K.; Tashima, K.; Horie, S.; Higuchi, Y.; Dominguez, O.P. Chemical constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid. J. Nat. Prod., 2008, 71(7), 1167-1172.
[http://dx.doi.org/10.1021/np800041t] [PMID: 18570470]
[24]
Pereira, M.D.P.; da Silva, T.; Aguiar, A.C.C.; Oliva, G.; Guido, R.V.C.; Yokoyama-Yasunaka, J.K.U.; Uliana, S.R.B.; Lopes, L.M.X. Chemical composition, antiprotozoal and cytotoxic activities of indole alkaloids and benzofuran neolignan of Aristolochia cordigera. Planta Med., 2017, 83(11), 912-920.
[http://dx.doi.org/10.1055/s-0043-104776] [PMID: 28264205]
[25]
Wu, T-S.; Chan, Y-Y.; Leu, Y-L. The constituents of the root and stem of Aristolochia cucurbitifolia hayata and their biological activity. Chem. Pharm. Bull. (Tokyo), 2000, 48(7), 1006-1009.
[http://dx.doi.org/10.1248/cpb.48.1006] [PMID: 10923831]
[26]
Sartorelli, P.; Carvalho, C.S.; Reimão, J.Q.; Lorenzi, H.; Tempone, A.G. Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera. Planta Med., 2010, 76(13), 1454-1456.
[http://dx.doi.org/10.1055/s-0029-1240952] [PMID: 20301059]
[27]
Li, Z.J.; Njateng, G.S.S.; He, W.J.; Zhang, H.X.; Gu, J.L.; Chen, S.N.; Du, Z.Z. Chemical composition and antimicrobial activity of the essential oil from the edible aromatic plant Aristolochia delavayi. Chem. Biodivers., 2013, 10(11), 2032-2041.
[http://dx.doi.org/10.1002/cbdv.201300066] [PMID: 24243612]
[28]
Jiménez-Arellanes, A.; León-Díaz, R.; Meckes, M.; Tapia, A.; Molina-Salinas, G.M.; Luna-Herrera, J.; Yépez-Mulia, L. Antiprotozoal and antimycobacterial activities of pure compounds from Aristolochia elegans rhizomes. Evid. Based Complement. Alternat. Med., 2012, 2012, 593403.
[http://dx.doi.org/10.1155/2012/593403] [PMID: 22454670]
[29]
Izquierdo, A.M.; Zapata, E.V.; Jiménez-Ferrer, J.E.; Muñoz, C.B.; Aparicio, A.J.; Torres, K.B.; Torres, L.O. Scorpion antivenom effect of micropropagated Aristolochia elegans. Pharm. Biol., 2010, 48(8), 891-896.
[http://dx.doi.org/10.3109/13880200903311110] [PMID: 20673176]
[30]
Pakrashi, A.; Pakrasi, P. Antifertility efficacy of the plant Aristolochia indica linn on mouse. Contraception, 1979, 20(1), 49-54.
[http://dx.doi.org/10.1016/0010-7824(79)90043-X] [PMID: 477316]
[31]
Shafi, P.M.; Rosamma, M.K.; Jamil, K.; Reddy, P.S. Antibacterial activity of the essential oil from Aristolochia indica. Fitoterapia, 2002, 73(5), 439-441.
[http://dx.doi.org/10.1016/S0367-326X(02)00130-2] [PMID: 12165346]
[32]
Murugan, M.; Mohan, V.R. Efficacy of different solvent extracts of Vitex trifolia L. and Aristolochia indica L. for potential antibacterial activity. Sci. Res. Report., 2012, 2(1), 110-114.
[33]
D’Souza, M.G.; Bheemappa, E.; Pai, V.K.; Byahatti, V.V.; Tule, C. In vitro study on anthelmintic activity of Aristolochia indica and A. tagala roots. Lat. Am. J. Pharm., 2011, 30(6), 1208-1210.
[34]
Abhishiktha, S.N.; Saba, S.; Shrunga, M.N.; Sunitha, K.L.; Prashith, K.T.R.; Raghavendra, H.L. Antimicrobial and radical scavenging efficacy of leaf and flower of Aristolochia indica Linn. Sci. Technol. Arts Res. J., 2015, 4(1), 103-108.
[http://dx.doi.org/10.4314/star.v4i1.17]
[35]
Messiano, G.B.; Vieira, L.; Machado, M.B.; Lopes, L.M.X.; de Bortoli, S.A.; Zukerman-Schpector, J. Evaluation of insecticidal activity of diterpenes and lignans from Aristolochia malmeana against Anticarsia gemmatalis. J. Agric. Food Chem., 2008, 56(8), 2655-2659.
[http://dx.doi.org/10.1021/jf703594z] [PMID: 18380460]
[36]
Hu, S.L.; Zhang, H.Q.; Chan, K.; Mei, Q.X. Studies on the toxicity of Aristolochia manshuriensis (Guanmuton). Toxicology, 2004, 198(1-3), 195-201.
[http://dx.doi.org/10.1016/j.tox.2004.01.026] [PMID: 15138042]
[37]
Chung, Y.M.; Chang, F.R.; Tseng, T.F.; Hwang, T.L.; Chen, L.C.; Wu, S.F.; Lee, C.L.; Lin, Z.Y.; Chuang, L.Y.; Su, J.H.; Wu, Y.C. A novel alkaloid, aristopyridinone A and anti-inflammatory phenanthrenes isolated from Aristolochia manshuriensis. Bioorg. Med. Chem. Lett., 2011, 21(6), 1792-1794.
[http://dx.doi.org/10.1016/j.bmcl.2011.01.067] [PMID: 21353775]
[38]
Hegde, V.R.; Borges, S.; Patel, M.; Das, P.R.; Wu, B.; Gullo, V.P.; Chan, T.M. New potential antitumor compounds from the plant Aristolochia manshuriensis as inhibitors of the CDK2 enzyme. Bioorg. Med. Chem. Lett., 2010, 20(4), 1344-1346.
[http://dx.doi.org/10.1016/j.bmcl.2010.01.018] [PMID: 20097074]
[39]
Alali, F.Q.; Tawaha, K.; Shehadeh, M.B.; Telfah, S. Phytochemical and biological investigation of Aristolochia maurorum L. Z. Naturforsch. C J. Biosci., 2006, 61(9-10), 685-691.
[http://dx.doi.org/10.1515/znc-2006-9-1013] [PMID: 17137115]
[40]
Nascimento, I.R.; Murata, A.T.; Bortoli, S.A.; Lopes, L.M.X. Insecticidal activity of chemical constituents from Aristolochia pubescens against Anticarsia gemmatalis larvae. Pest Manag. Sci., 2004, 60(4), 413-416.
[http://dx.doi.org/10.1002/ps.805] [PMID: 15119605]
[41]
Pistelli, L.; Nieri, E.; Bilia, A.R.; Marsili, A.; Scarpato, R. Chemical constituents of Aristolochia rigida and mutagenic activity of aristolochic acid IV. J. Nat. Prod., 1993, 56(9), 1605-1608.
[http://dx.doi.org/10.1021/np50099a024] [PMID: 8254354]
[42]
Akindele, A.J.; Wani, Z.; Mahajan, G.; Sharma, S.; Aigbe, F.R.; Satti, N.; Adeyemi, O.O.; Mondhe, D.M. Anticancer activity of Aristolochia ringens Vahl. (Aristolochiaceae). J. Tradit. Complement. Med., 2014, 5(1), 35-41.
[http://dx.doi.org/10.1016/j.jtcme.2014.05.001] [PMID: 26151007]
[43]
Aigbe, F.R.; Adeyemi, O.O. The aqueous root extract of Aristolochia ringens (Vahl.) prevents chemically induced inflammation. Planta Med., 2011, 77(12), 35-41.
[http://dx.doi.org/10.1055/s-0031-1282416]
[44]
Battu, G.R.; Parimi, R.; Chandra Shekar, K.B. In vivo and in vitro pharmacological activity of Aristolochia tagala (syn: Aristolochia acuminata) root extracts. Pharm. Biol., 2011, 49(11), 1210-1214.
[http://dx.doi.org/10.3109/13880209.2011.589855] [PMID: 21846201]
[45]
León-Díaz, R.; Meckes, M.; Said-Fernández, S.; Molina-Salinas, G.M.; Vargas-Villarreal, J.; Torres, J.; Luna-Herrera, J.; Jiménez-Arellanes, A. Antimycobacterial neolignans isolated from Aristolochia taliscana. Mem. Inst. Oswaldo Cruz, 2010, 105(1), 45-51.
[http://dx.doi.org/10.1590/S0074-02762010000100006] [PMID: 20209328]
[46]
Oliveira, S.Q.; Kratz, J.M.; Chaves, V.C.; Guimarães, T.R.; Costa, D.T.M.; Dimitrakoudi, S.; Vontzalidou, A.; Bordignon, S.A.L.; Simionato, C.P.; Steindel, M.; Reginatto, F.H.; Simões, C.M.O.; Schenkel, E.P. Chemical constituents and pharmacology properties of Aristolochia triangularis: A south Brazilian highly-consumed botanical with multiple bioactivities. An. Acad. Bras. Cienc., 2019, 91(3), e20180621.
[http://dx.doi.org/10.1590/0001-3765201920180621] [PMID: 31411258]
[47]
El Omari, N.; Sayah, K.; Fettach, S.; El Blidi, O.; Bouyahya, A.; Faouzi, M.E.A.; Kamal, R.; Barkiyou, M. Evaluation of in vitro antioxidant and antidiabetic activities of Aristolochia longa extracts. Evid. Based Complement. Alternat. Med., 2019, 2019, 7384735.
[http://dx.doi.org/10.1155/2019/7384735] [PMID: 31061671]
[48]
Kuo, P-C.; Li, Y-C.; Wu, T-S. Chemical constituents and pharmacology of the Aristolochia (馬兜鈴 mădōu ling) species. J. Tradit. Complement. Med., 2012, 2(4), 249-266.
[http://dx.doi.org/10.1016/S2225-4110(16)30111-0] [PMID: 24716140]
[49]
Pacheco, A.G.; Machado de Oliveira, P.; Piló-Veloso, D.; Flávio de Carvalho Alcântara, A. 13C-NMR data of diterpenes isolated from Aristolochia species. Molecules, 2009, 14(3), 1245-1262.
[http://dx.doi.org/10.3390/molecules14031245] [PMID: 19325521]
[50]
Akbar, S. Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications, 1st ed; Springer: Stockton, CA, USA, 2020.
[51]
Sana, S.H. A comprehensive review of the pharmacological potential of Aristolochia longa linn. EJPMR, 2020, 7(8), 366-368.
[52]
Merouani, N.; Boukhebti, H.; Belhattab, R. Ethnobotanical study, anatomical study and phytochemical screening of Aristolochia longa L. J. Drug Deliv. Ther., 2020, 10(4), 112-124.
[http://dx.doi.org/10.22270/jddt.v10i4.4160]
[53]
Costa, A. Taxonomy of an endemic Aristolochia [Aristolochiaceae] from the Iberian Peninsula. An. Jardin Botanico Madr. 1979, 2008, 65(2), 173-178.
[http://dx.doi.org/10.3989/ajbm.2008.v65.i2.290]
[54]
El Fakir, L.; Bito, V.; Zaid, A.; Alaoui, T.M. Complimentary herbal treatments used in Meknes-Tafilalet region (Morocco) to manage cancer. Am. J. Plant Sci., 2019, 10(5), 796-812.
[http://dx.doi.org/10.4236/ajps.2019.105058]
[55]
Bourhia, M.; Abdelaziz Shahat, A.; Mohammed Almarfadi, O.; Ali Naser, F.; Mostafa Abdelmageed, W.; Ait Haj Said, A.; El Gueddari, F.; Naamane, A.; Benbacer, L.; Khlil, N. Ethnopharmacological survey of herbal remedies used for the treatment of cancer in the greater Casablanca-Morocco. Evid. Based Complement. Alternat. Med., 2019, 2019, 1613457.
[http://dx.doi.org/10.1155/2019/1613457] [PMID: 31687035]
[56]
Talbaoui, A.; Bouyahya, A.; Bakri, Y. Ethnobotanical study on the Bereztem plant (Aristolochia longa) used in the treatment of some diseases in the cities of Rabat, Sale and Temara (Morocco). JMES, 2018, 9(6), 1914-1921.
[57]
Samouh, Y.; Lemrani, A.; Mimouni, H.; Mohamad, J.; Ait Haj Said, A. Ethnopharmacological study of herbal medicines used to treat cancer in Morocco. J. Phytopharmacol., 2019, 8(3), 135-141.
[http://dx.doi.org/10.31254/phyto.2019.8309]
[58]
Yamani, A.; Bunel, V.; Antoine, M.H.; Husson, C.; Stévigny, C.; Duez, P.; Elachouri, M.; Nortier, J. Substitution between Aristolochia and Bryonia genus in North-Eastern Morocco: Toxicological implications. J. Ethnopharmacol., 2015, 166, 250-260.
[http://dx.doi.org/10.1016/j.jep.2015.03.036] [PMID: 25797117]
[59]
El Hachlafi, N.; Chebat, A.; Bencheikh, R.S.; Fikri-Benbrahim, K. Ethno-pharmacological study of medicinal plants used for chronic diseases treatment in Rabat-Sale-Kenitra region (Morocco). Ethnobot. Res. Appl., 2020, 20(2), 1-23.
[60]
Daoudi, A.; Youbi, A.E.H.E.L.; Bagrel, D.; Aarab, L. In vitro anticancer activity of some plants used in Moroccan traditional medicine. J. Med. Plants Res., 2013, 7(17), 1182-1189.
[61]
Benali, T.; Khabbach, A.; Ennabili, A.; Hammani, K. Ethnopharmacological prospecting of medicinal plants from the province of Guercif (NE of Morocco). Moroccan J. Biol., 2017, 14, 1-14.
[62]
Benarba, B.; Meddah, B. Ethnobotanical study, antifungal activity, phytochemical screening and total phenolic content of Algerian Aristolochia longa. J. Intercult. Ethnopharmacol., 2014, 3(4), 150-154.
[http://dx.doi.org/10.5455/jice.20140826030222] [PMID: 26401365]
[63]
Youbi, A.; Ouahidi, I.; Mansouri, L.; Daoudi, A.; Bousta, D. Ethnopharmacological survey of plants used for immunological diseases in four regions of Morocco. European J. Med. Plants, 2016, 13(1), 1-24.
[http://dx.doi.org/10.9734/EJMP/2016/12946]
[64]
El Haouari, M.; El Makaoui, S.; Jnah, M.; Haddaouy, A. A survey of medicinal plants used by herbalists in Taza (Northern Morocco) to manage various ailments. J. Mater. Environ. Sci., 2018, 9(6), 1875-1888.
[65]
Alami, Z.; Aynaou, H.; Alami, B.; Hdidou, Y.; Latrech, H. Herbal medicines use among diabetic patients in oriental Morocco. J. Pharmacogn. Phytother., 2015, 7(2), 9-17.
[http://dx.doi.org/10.5897/JPP2014.0338]
[66]
Fatiha, B.A.; Souad, S.; Ouafae, B.; Jamila, D.; Allal, D.; Lahcen, Z. Ethnobotanical study of medicinal plants used in the region of middle Oum Rbia (Morocco). Plant Arch., 2019, 19(2), 2005-2017.
[67]
Merzouki, A.; Ed-derfoufi, F.; Molero-Mesa, J. Contribution to the knowledge of Rifian traditional medicine. II: Folk medicine in Ksar Lakbir district (NW Morocco). Fitoterapia, 2000, 71(3), 278-307.
[http://dx.doi.org/10.1016/S0367-326X(00)00139-8] [PMID: 10844168]
[68]
El-Hilaly, J.; Hmammouchi, M.; Lyoussi, B. Ethnobotanical studies and economic evaluation of medicinal plants in Taounate province (Northern Morocco). J. Ethnopharmacol., 2003, 86(2-3), 149-158.
[http://dx.doi.org/10.1016/S0378-8741(03)00012-6] [PMID: 12738079]
[69]
Hachi, M.; Hachi, T.; Belahbib, N.; Dahmani, J.; Zidane, L. Contribution à l’étude floristique et ethnobotanique de la flore medicinale utilisée au niveau de la ville de Khenifra (Maroc). IJIAS, 2015, 11(3), 754-770.
[70]
(a) Derouiche, S.; Zeghib, K.; Gharbi, S.; Khelef, Y. Beneficial effects of Aristolochia longa and Aquilaria malaccensis on lead-induced hematological alterations and heart oxidative stress in rats. J. Chem. Pharm. Res., 2018, 10(9), 8-15.
(b) Derouiche, S.; Zeghib, K.; Gharbi, S.; Khelef, Y.; Feriani, A. Protective effects of Aristolochia longa and Aquilaria malaccensis against lead induced acute liver injury in rats. J. Acute Dis., 2017, 6(5), 193-197.
[http://dx.doi.org/10.4103/2221-6189.219611]
[71]
Merouani, N.; Belhattab, R.; Sahli, F. Evaluation of the biological activity of Aristolochia longa L. extracts. Int. J. Pharm. Sci. Res., 2017, 8(5), 1978-1992.
[72]
Bourhia, M. F.E.; Laasri, S.I.; Moussa, R.; Ullah, A.; Bari, S.; Saeed, A.; Benbacer, L. Phytochemistry, antioxidant activity, antiproliferative effect and acute toxicity testing of two Moroccan Aristolochia species. Evid. Based Complement. Alternat. Med., 2019, 2019, 1-8.
[PMID: 31885676]
[73]
Mix, D.B.; Guinaudeau, H.; Shamma, M. The aristolochic acids and aristolactams. J. Nat. Prod., 1982, 45(6), 657-666.
[http://dx.doi.org/10.1021/np50024a001]
[74]
Hinou, J.; Demetzos, C.; Harvala, C.; Roussakis, C. Cytotoxic and antimicrobial principles from the roots of Aristolochia longa. Int. J. Crude Drug Res., 1990, 28(2), 149-151.
[http://dx.doi.org/10.3109/13880209009082801]
[75]
Al-Barham, M.B.; Al-Jaber, H.I.; Al-Qudah, M.A.; Abu Zarga, M.H. New aristolochic acid and other chemical constituents of Aristolochia maurorum growing wild in Jordan. Nat. Prod. Res., 2017, 31(3), 245-252.
[http://dx.doi.org/10.1080/14786419.2016.1226833] [PMID: 27628622]
[76]
Kumar, M.H.; Prabhu, K.; Rao, M.R.K.; Sundram, R.L.; Shil, S.; Kumar, M.S.; Vijayalakshmi, N. The gas chromatography–mass spectrometry study of one medicinal plant, Aristolochia indica. Drug Invent Today, 2019, 12(12), 2919-2923.
[77]
Talbaoui, A.; Bouyahya, A.; Boury, H.E.; Amzazi, S.; Benjouad, A.; Dakka, N.; Bakri, Y. In vitro cytotoxic effects and antibacterial activity of Moroccan medicinal plants Aristolochia longa and Lavandula multifida. European J. Med. Plants, 2016, 16(2), 1-13.
[http://dx.doi.org/10.9734/EJMP/2016/28534]
[78]
Bouteldja, R.; Doucene, R.; Bouzid, R.; Moulay, M.; Aggad, H. Biological activity of Aristolochia longa l. Against some pathogenic bacteria and phytochemical screening. Lucr. Ştiinţific, 2019, III(3), 23.
[79]
Dhouioui, M.; Boulila, A.; Chaabane, H.; Zina, M.S.; Casabianca, H. Seasonal changes in essential oil composition of Aristolochia longa L. ssp. Paucinervis batt. (Aristolochiaceae) roots and its antimicrobial activity. Ind. Crops Prod., 2016, 83, 301-306.
[http://dx.doi.org/10.1016/j.indcrop.2016.01.025]
[80]
Gadhi, C.A.; Benharref, A.; Jana, M.; Basile, A.M.; Contet-Audonneau, N.; Fortier, B. Antidermatophytic properties of extracts from the leaves of Aristolochia paucinervis Pomel. Phytother. Res., 2001, 15(1), 79-81.
[http://dx.doi.org/10.1002/1099-1573(200102)15:1<79:AID-PTR953>3.0.CO;2-K] [PMID: 11180530]
[81]
Mohamed, M.S.; Idriss, M.T.; Khedr, M.; Al Gadir, A.M.A.; Takeshita, H.; Shah, S.; Ichinose, M.M.; Maki, Y.T.M. Activity of Aristolochia bracteolata against Moraxella catarrhalis. Int. J. Bacteriol., 2014, 2014, 481686.
[PMID: 26904734]
[82]
Attou, S.; Meddah, B. Phytochemical screening and antioxidant activity of Algerian Aristolochia longa flavonoids. J. Appl. Biotechnol. Rep., 2020, 7(3), 166-170.
[83]
Ruffa, M.J.; Ferraro, G.; Wagner, M.L.; Calcagno, M.L.; Campos, R.H.; Cavallaro, L. Cytotoxic effect of Argentine medicinal plant extracts on human hepatocellular carcinoma cell line. J. Ethnopharmacol., 2002, 79(3), 335-339.
[http://dx.doi.org/10.1016/S0378-8741(01)00400-7] [PMID: 11849838]
[84]
Chaouki, W.; Leger, D.Y.; Eljastimi, J.; Beneytout, J-L.; Hmamouchi, M. Antiproliferative effect of extracts from Aristolochia baetica and Origanum compactum on human breast cancer cell line MCF-7. Pharm. Biol., 2010, 48(3), 269-274.
[http://dx.doi.org/10.3109/13880200903096588] [PMID: 20645812]
[85]
Masud Rana, A.Y.K.M.; Khanam, J.A. Aristolochia indica whole plant extract as an antineoplastic agent. J. Med. Sci. (Faisalabad, Pak.), 2002, 2(4), 202-205.
[http://dx.doi.org/10.3923/jms.2002.202.205]
[86]
Klein, S. Substances which inhibit the growth of tumors. J. Am. Chem. Soc., 1962, 57, 2350-2350.
[87]
Mongelli, E.; Pampuro, S.; Coussio, J.; Salomon, H.; Ciccia, G. Cytotoxic and DNA interaction activities of extracts from medicinal plants used in Argentina. J. Ethnopharmacol., 2000, 71(1-2), 145-151.
[http://dx.doi.org/10.1016/S0378-8741(99)00195-6] [PMID: 10904157]
[88]
Das, R.; Kausik, A.; Pal, T.K. Anti-inflammatory activity study of antidote Aristolochia indica to the venom of Heteropneustes fossilis in rats. J. Chem. Pharm. Res., 2010, 2(2), 554-562.
[89]
Chen, Z.L.; Zhu, D.Y. Aristolochia alkaloids. Alkaloids Chem. Parm., 1987, 31, 29-65.
[90]
Racheli, T.; Oliverio, M. Biogeographical patterns of the neotropical genus Battus Scopoli 1777 (Lepidoptera Papilionidae). Trop. Zool., 1993, 6(1), 55-65.
[http://dx.doi.org/10.1080/03946975.1993.10539208]
[91]
Brower, J.V.Z. Experimental studies of mimicry in some North American butterflies. Part II Battusphilenor and Papiliotroilus, P. polyxenes and P. glaucus. Evolution, 1958, 12(2), 123-136.
[http://dx.doi.org/10.1111/j.1558-5646.1958.tb02939.x]
[92]
Rothschild, M.; Reichstein, T.; von Euw, J.; Aplin, R.; Harman, R.R.M. Toxic Lepidoptera. Toxicon, 1970, 8(4), 293-299.
[http://dx.doi.org/10.1016/0041-0101(70)90006-1] [PMID: 5531242]
[93]
Codella, S.G., Jr; Lederhouse, R.C. Intersexual comparison of mimetic protection in the black swallowtail butterfly, Papiliopolyxenes: Experiments with captive blue jay predators. Evolution, 1989, 43(2), 410-420.
[PMID: 28568560]
[94]
Fordyce, J.A. The lethal plant defense paradox remains: Inducible host-plant aristolochic acids and the growth and defense of the pipevine swallowtail. Entomol. Exp. Appl., 2001, 100(3), 339-346.
[http://dx.doi.org/10.1046/j.1570-7458.2001.00881.x]
[95]
Su, T.; Qu, L.; Zhang, C.L.; Cai, S.Q.; Li, X.M. Studies on pharmacodynamic characteristics of aristolochic acid I in rats. Zhongguo Zhongyao Zazhi, 2004, 29(7), 676-681.

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy